Oxidative Medicine and Cellular Longevity

Oxidative Stress, Chronic Inflammation, and Amyloidoses


Publishing date
01 Aug 2019
Status
Published
Submission deadline
15 Mar 2019

1Warsaw University of Life Sciences, Warsaw, Poland

2New York University, New York City, USA

3Universitá degli Studi di Parma, Parma, Italy


Oxidative Stress, Chronic Inflammation, and Amyloidoses

Description

The inflammatory response, elicited by body tissues as a result of harmful stimuli including oxidative stress, is a set of sequential events attempting to promote healing and shield viable tissue from additional injuries. It results from the action of host biomolecules acting as mediators of inflammation including Damage-Associated Molecular Patterns—DAMPs—and Pathogen-Associated Molecular Patterns—PAMPs—and brings forth the production of proinflammatory cytokines (PCs). In spite of the acute beneficial effects of these PCs, uncontrolled inflammation, reactive oxygen species (ROS), and ROS-induced injuries are central to almost every major disease, including cancer, diabetes, neurodegenerative conditions, and amyloidosis. The latter is a pathologic process in which structural transitions of normally soluble proteins into polymeric aggregates generate poorly soluble fibrillar extracellular tissue deposits with higher incidence in the elderly. Aggregation of antiparallel β-pleated amyloid fibrils is observed in the parenchyma and very often in blood vessels of different organs, causing compression, ischemia, organ dysfunction, and cell ultimately death with increasing geriatric age. Originally grouped into primary, secondary, and familial types based on the clinical characteristics, a more modern protein-based classification of amyloid diseases has contributed to a better understanding of the disease pathogenesis. At the present time 30 different proteins and more than 100 genetic variants are known to be associated with systemic and localized forms of the disease in humans. The most frequently diagnosed form of systemic amyloidosis—about 60% of the cases—is associated with the deposition of Immunoglobulin Light chains, generally as a complication of monoclonal gammopathies. Among cerebral amyloidosis, parenchymal and vascular deposition of the amyloid-β (Aβ) protein in patients with Alzheimer’s disease constitutes the most common form in aging dogs and humans. In recent decades, chronic inflammation and oxidative stress have emerged as crucial players in the disease pathogenesis of many—if not all—of these forms of amyloidosis irrespective of the tissue localization and biochemical composition of the deposits, emerging as an attractive translational target for novel therapeutic interventions.

This special issue is intended to provide an updated view on the role of proinflammatory cytokines and inflammation induced by oxidative stress and its related cellular pathways in the etiopathogenesis and treatment strategies of amyloidosis.

Potential topics include but are not limited to the following:

  • Influence of PCs on the secretion and fibrillogenic processing of protein substrates and generation of ROS in amyloidoses
  • Identification of the proinflammatory mechanisms influencing amyloidogenesis
  • Description of new cellular and animal models aiding in the understanding of the role of inflammation-related mechanisms in different types of amyloid diseases associated with ROS-mediated cytotoxicity
  • Neuroinflammation as an emerging factor modulating neurodegenerative diseases associated with amyloid deposition and oxidative stress
  • Modalities, future therapeutic strategies, drugs, and prospects for the removal of amyloid deposits to limit harmful effects of ROS

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 6024975
  • - Editorial

Oxidative Stress, Chronic Inflammation, and Amyloidoses

Arkadiusz Orzechowski | Anna Cywińska | ... | Federica M. Rizzi
  • Special Issue
  • - Volume 2019
  • - Article ID 7935310
  • - Review Article

Hypoxia and Inflammation as a Consequence of β-Fibril Accumulation: A Perspective View for New Potential Therapeutic Targets

Matteo A. Russo | Carlo Tomino | ... | Marco Tafani
  • Special Issue
  • - Volume 2019
  • - Article ID 5030475
  • - Research Article

High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse

Rebecca Piccarducci | Deborah Pietrobono | ... | Claudia Martini
  • Special Issue
  • - Volume 2019
  • - Article ID 1263274
  • - Research Article

Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors

Jian Dai | Xin Ding | ... | Keiichi Higuchi
  • Special Issue
  • - Volume 2019
  • - Article ID 6927380
  • - Research Article

Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes

Matylda B. Mielcarska | Magdalena Bossowska-Nowicka | ... | Felix N. Toka
  • Special Issue
  • - Volume 2019
  • - Article ID 2302835
  • - Research Article

Nitric Oxide Influences HSV-1-Induced Neuroinflammation

Joanna Cymerys | Andrzej Kowalczyk | ... | Małgorzata Krzyżowska
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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