Oxidative Medicine and Cellular Longevity

Mitochondrial Health in Aging and Age-Related Metabolic Disease


Publishing date
13 May 2016
Status
Published
Submission deadline
25 Dec 2015

1Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain

2Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

3Shiga University of Medical Science, Otsu, Japan


Mitochondrial Health in Aging and Age-Related Metabolic Disease

Description

Historically, mitochondria have been exclusively considered as the centers for energy production in the cell. However, besides respiration and production of ATP, mitochondria are central regulators of many other cellular functions, such as apoptosis, autophagy, and Ca2+ homeostasis. Therefore, alterations in mitochondrial biology and function have a major impact on pathology and disease. A hallmark of aging is the presence of a decline in mitochondrial function, associated to a reduced number and morphological alterations of mitochondria, reduction in mitochondrial respiration, and increased oxidative stress. However, there is still debate about whether mitochondrial dysfunction could be driving some of the age-related alterations or, on the contrary, age-associated mitochondrial dysfunction might be secondary to aging itself. In the last years, some of the mechanisms involved in mitochondrial quality control have been described, but whether alterations in them could contribute to the loss of mitochondrial health observed during aging and age-related alterations is still under investigation.

We invite investigators to contribute original research articles as well as review articles aimed to elucidate the mechanisms responsible for the loss of mitochondrial health and their connection with aging and age-related pathologies, with particular emphasis age-related metabolic disease.

Potential topics include, but are not limited to:

  • Mitochondrial quality control
  • Mitochondrial energy metabolism
  • Mitochondrial dynamics
  • Mitophagy
  • Alterations in signaling pathways connecting mitochondria and nutrient sensing
  • Mitochondrial oxidative stress and antioxidants
  • Alterations in mitochondrial structure/morphology in aging
  • Mitochondrial calcium homeostasis

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5831538
  • - Editorial

Mitochondrial Health in Aging and Age-Related Metabolic Disease

David Sebastián | Rebeca Acín-Pérez | Katsutaro Morino
  • Special Issue
  • - Volume 2016
  • - Article ID 1735841
  • - Research Article

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

Hirotaka Yamamoto | Katsutaro Morino | ... | Hiroshi Maegawa
  • Special Issue
  • - Volume 2016
  • - Article ID 8679469
  • - Research Article

Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Alexey V. Lokhmatikov | Natalia Voskoboynikova | ... | Armen Y. Mulkidjanian
  • Special Issue
  • - Volume 2016
  • - Article ID 8470394
  • - Research Article

Assessment of Mitochondrial Dysfunction and Monoamine Oxidase Contribution to Oxidative Stress in Human Diabetic Hearts

O. M. Duicu | R. Lighezan | ... | C. Mornos
  • Special Issue
  • - Volume 2016
  • - Article ID 8360738
  • - Research Article

AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

Feng-li Zhao | Fang Fang | ... | Yong Yan
  • Special Issue
  • - Volume 2016
  • - Article ID 8296150
  • - Research Article

Proliferation of Human Primary Myoblasts Is Associated with Altered Energy Metabolism in Dependence on Ageing In Vivo and In Vitro

Reedik Pääsuke | Margus Eimre | ... | Kalju Paju
  • Special Issue
  • - Volume 2016
  • - Article ID 6705621
  • - Research Article

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity

Kaige Peng | Yuan Tao | ... | Yan Sai
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision78 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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