Many chronic diseases are characterized by excessive oxidative stress and inflammation. The recent escalation of chronic conditions like obesity, insulin resistance, diabetes, hypertension, and other related cardiometabolic complications in all ages of the population including children, adolescencents, and adults poses a great challenge to health care systems. Many cardiometabolic complications are multifactorial diseases, and a wide variety of etiological factors including genetic, habitual, environmental, and epigenetic ones may be involved. These factors perturb the physiological milieu in different ways; however it has been consistently shown that a common denominator amongst these factors is the production of increased oxidative stress and inflammation at various stages during the progression and development of many cardiometabolic disorders. Although significant strides have been made in elucidating the role of oxidative stress and inflammation in insulin resistance, diabetes, and many cardiometabolic diseases, novel mechanistic studies are needed to broaden our knowledge about the treatment and management of these chronic conditions.

Therefore, this special issue will welcome review papers and research articles that address novel mechanistic paradigms that address oxidative stress and inflammation in insulin resistance, diabetes, hypertension, obesity, and related cardiometabolic complications. Potential topics include, but are not limited to:

• The effect of oxidative stress and inflammation on environmental and epigenetic factors: impact on diabetes, obesity, and hypertension
• Novel therapeutic strategies targeting oxidative and inflammatory mediators in obesity, diabetes, and hypertension
• Novel prognostic interventions for diabetes and hypertension targeting oxidative and inflammatory agents
• The impact of obesity on inflammation and oxidative stress
• The role of oxidative stress and inflammation in cardiometabolic complications including heart disease, nephropathy, vasculopathy, neuropathy, and so forth

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/oximed/osio/ according to the following timetable: