Oxidative Medicine and Cellular Longevity

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects


Publishing date
01 Jan 2016
Status
Published
Submission deadline
14 Aug 2015

Lead Editor

1Sapienza University of Rome, Rome, Italy

2Centre for Innovative Biotechnological Research, Moscow, Russia

3Akdeniz University, Antalya, Turkey


Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects

Description

Reactive oxygen (ROS) and nitrogen (RNS) species are generated as by-products of normal cellular metabolic activities and have been implicated in the pathogenesis of a variety of diseases. Disruption of normal cellular homeostasis by redox signaling may result in chronic infections, inflammatory disorders, cardiovascular and neurodegenerative diseases, and cancer.

Notwithstanding that the multiple roles of oxidative stress in human normal biology and pathology have been intensely discussed over last half-a-century, the problem is still far beyond our full comprehension. Thus, in a comparatively short history of oxidative medicine, the roles free radicals and antioxidants have been entirely redefined. Some negative actions of free radicals and ROS in human biology and pathology, widely recognized two-three decades ago, have been subsequently transformed into positive ones, in the appreciation of their essential impact in the intracellular signaling on the organism’s defense against biotic and abiotic stresses. On the other hand, the great hope that direct antioxidants could be the panacea resolving practically all health problems has vanished, due to the growing number of inconclusive or negative data from epidemiological and clinical studies.

The current state of uncertainty regarding feasibility of antioxidant therapy is partly due to methodological pitfalls in the drug development and delivery, the limited and often overlooked knowledge regarding the antioxidant metabolism and their interaction with physiologically important molecular/cellular processes in the organism, and the lack of correlations between biological markers of oxidative stress and clinical outcomes. Modulation of oxidative stress is important to develop new therapies to manage a variety of conditions for which current therapies are not effective.

The main aim of this special issue is to address different pharmaceutical and pharmacological aspects of research related to modulation of oxidative stress. In particular, contributions focused on the following issues will be particularly welcome.

Potential topics include, but are not limited to:

  • Synthesis and derivatization of antioxidant compounds with potential pharmacological applications to modulate their antioxidant properties and bioavailability
  • Mechanism of action of antioxidant compounds with special attention to the Nrf2/ARE signaling pathway
  • Pharmacokinetics, metabolic pathways, and antioxidant activity of metabolites
  • Optimization of delivery systems
  • In vitro and in vivo studies on the pharmacological activity of antioxidants
  • Epidemiological and clinical studies on the efficacy of antioxidant therapies
  • Relevant biological markers to assess in vivo antioxidant/prooxidant action and its correlation with clinical efficacy

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 6023417
  • - Editorial

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects

Liudmila Korkina | Tomris Ozben | Luciano Saso
  • Special Issue
  • - Volume 2016
  • - Article ID 4389410
  • - Clinical Study

Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study

Chiara De Luca | Elena V. Mikhal’chik | ... | Liudmila G. Korkina
  • Special Issue
  • - Volume 2016
  • - Article ID 1892412
  • - Review Article

1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Astrida Velena | Neven Zarkovic | ... | Gunars Duburs
  • Special Issue
  • - Volume 2016
  • - Article ID 4251912
  • - Review Article

Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants

Aysegul Cort | Tomris Ozben | ... | Liudmila Korkina
  • Special Issue
  • - Volume 2016
  • - Article ID 3187560
  • - Research Article

Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber’s Hereditary Optic Neuropathy Cells

Micol Falabella | Elena Forte | ... | Paolo Sarti
  • Special Issue
  • - Volume 2016
  • - Article ID 7909380
  • - Review Article

Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases

Valerio Chiurchiù | Antonio Orlacchio | Mauro Maccarrone
  • Special Issue
  • - Volume 2016
  • - Article ID 7239639
  • - Review Article

Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases

Nada Sallam | Ismail Laher
  • Special Issue
  • - Volume 2016
  • - Article ID 8408479
  • - Review Article

Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress

Manuela Graziani | Letizia Antonilli | ... | Luciano Saso
  • Special Issue
  • - Volume 2016
  • - Article ID 3578368
  • - Review Article

Oxidative Stress in Shiga Toxin Production by Enterohemorrhagic Escherichia coli

Katarzyna Licznerska | Bożena Nejman-Faleńczyk | ... | Grzegorz Węgrzyn
  • Special Issue
  • - Volume 2016
  • - Article ID 8453135
  • - Research Article

The Role of the Exo-Xis Region in Oxidative Stress-Mediated Induction of Shiga Toxin-Converting Prophages

Katarzyna Licznerska | Aleksandra Dydecka | ... | Grzegorz Węgrzyn
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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