Oxidative Medicine and Cellular Longevity

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects


Publishing date
01 Jan 2016
Status
Published
Submission deadline
14 Aug 2015

Lead Editor

1Sapienza University of Rome, Rome, Italy

2Centre for Innovative Biotechnological Research, Moscow, Russia

3Akdeniz University, Antalya, Turkey


Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects

Description

Reactive oxygen (ROS) and nitrogen (RNS) species are generated as by-products of normal cellular metabolic activities and have been implicated in the pathogenesis of a variety of diseases. Disruption of normal cellular homeostasis by redox signaling may result in chronic infections, inflammatory disorders, cardiovascular and neurodegenerative diseases, and cancer.

Notwithstanding that the multiple roles of oxidative stress in human normal biology and pathology have been intensely discussed over last half-a-century, the problem is still far beyond our full comprehension. Thus, in a comparatively short history of oxidative medicine, the roles free radicals and antioxidants have been entirely redefined. Some negative actions of free radicals and ROS in human biology and pathology, widely recognized two-three decades ago, have been subsequently transformed into positive ones, in the appreciation of their essential impact in the intracellular signaling on the organism’s defense against biotic and abiotic stresses. On the other hand, the great hope that direct antioxidants could be the panacea resolving practically all health problems has vanished, due to the growing number of inconclusive or negative data from epidemiological and clinical studies.

The current state of uncertainty regarding feasibility of antioxidant therapy is partly due to methodological pitfalls in the drug development and delivery, the limited and often overlooked knowledge regarding the antioxidant metabolism and their interaction with physiologically important molecular/cellular processes in the organism, and the lack of correlations between biological markers of oxidative stress and clinical outcomes. Modulation of oxidative stress is important to develop new therapies to manage a variety of conditions for which current therapies are not effective.

The main aim of this special issue is to address different pharmaceutical and pharmacological aspects of research related to modulation of oxidative stress. In particular, contributions focused on the following issues will be particularly welcome.

Potential topics include, but are not limited to:

  • Synthesis and derivatization of antioxidant compounds with potential pharmacological applications to modulate their antioxidant properties and bioavailability
  • Mechanism of action of antioxidant compounds with special attention to the Nrf2/ARE signaling pathway
  • Pharmacokinetics, metabolic pathways, and antioxidant activity of metabolites
  • Optimization of delivery systems
  • In vitro and in vivo studies on the pharmacological activity of antioxidants
  • Epidemiological and clinical studies on the efficacy of antioxidant therapies
  • Relevant biological markers to assess in vivo antioxidant/prooxidant action and its correlation with clinical efficacy

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 7409196
  • - Research Article

Apocynin and Diphenyleneiodonium Induce Oxidative Stress and Modulate PI3K/Akt and MAPK/Erk Activity in Mouse Embryonic Stem Cells

Jan Kučera | Lucia Binó | ... | Jiří Pacherník
  • Special Issue
  • - Volume 2016
  • - Article ID 5213532
  • - Research Article

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

Michal Říha | Pavlína Hašková | ... | Přemysl Mladěnka
  • Special Issue
  • - Volume 2016
  • - Article ID 3863726
  • - Review Article

Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart

Csaba Csonka | Márta Sárközy | ... | Tamás Csont
  • Special Issue
  • - Volume 2016
  • - Article ID 9268531
  • - Research Article

A New Method to Simultaneously Quantify the Antioxidants: Carotenes, Xanthophylls, and Vitamin A in Human Plasma

Mariel Colmán-Martínez | Miriam Martínez-Huélamo | ... | Rosa M. Lamuela-Raventós
  • Special Issue
  • - Volume 2016
  • - Article ID 4985063
  • - Research Article

Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer

K. Yanar | U. Çakatay | ... | İ. Yaylım
  • Special Issue
  • - Volume 2016
  • - Article ID 8214631
  • - Research Article

The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes

Andreia Ascenso | Tiago Pedrosa | ... | Conceição Santos
  • Special Issue
  • - Volume 2016
  • - Article ID 6859523
  • - Review Article

Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases

Zhong-Wei Zhang | Xiao-Chao Xu | ... | Shu Yuan
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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