Oxidative Medicine and Cellular Longevity

Oxidative Stress and Cancer: Advances and Challenges


Status
Published

Lead Editor

1University of Texas MD Anderson Cancer Center, Houston, USA

2University of Mississippi Medical Center, Mississippi, USA

3Penn State Milton S. Hershey Medical Center, Pennsylvania, USA

4Institute of Bioresources and Sustainable Development (IBSD), Imphal, India


Oxidative Stress and Cancer: Advances and Challenges

Description

Cancer is a chronic disease caused by dysregulation of multiple genes and requires more than 25 years for development. Accumulating evidence suggests that reactive oxygen species (ROS) generated inside body under normal physiologic conditions are also critically involved in regulating tumor functions. Recent advancement in free radical biology and tumor biology suggests that ROS control numerous aspects of tumor development such as drug resistance, epithelial-to-mesenchymal transition, and cancer stemness. ROS have been demonstrated to regulate multistep process of tumor development including inflammation, transformation, survival, proliferation, invasion, angiogenesis, and metastasis by activating various oncogenic transcription factors. Paradoxically, ROS also control the expression of various tumor suppressor genes such as p53, Rb, and PTEN. Similarly, γ-radiation and various chemotherapeutic agents used to treat cancer mediate their effects through the production of ROS. This paradox provides a great challenge for researchers whose aim is to exploit ROS stress for the development of cancer therapies. Thus, a thorough assessment of current developments concerning role of ROS in tumor biology is required.

We invite authors around the world to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the role of ROS in tumor development. We are particularly interested in thought-provoking articles that provide an overview of existing concepts, novel findings, controversies, and challenges concerning the role of ROS in cancer development. Articles on future prospects of targeting ROS associated signaling molecules in cancer therapy are invited.

Potential topics include, but are not limited to:

  • ROS and drug resistance
  • ROS and multisteps of tumor development
  • ROS and cancer therapy
  • ROS and cancer stem cells
  • ROS and inflammation
  • ROS and cancer cell metabolism
  • ROS and dietary agents/nutraceuticals

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5010423
  • - Editorial

Oxidative Stress and Cancer: Advances and Challenges

Sahdeo Prasad | Subash C. Gupta | ... | Lokesh Deb
  • Special Issue
  • - Volume 2016
  • - Article ID 2727403
  • - Research Article

Raman Spectroscopic Measurements of Dermal Carotenoids in Breast Cancer Operated Patients Provide Evidence for the Positive Impact of a Dietary Regimen Rich in Fruit and Vegetables on Body Oxidative Stress and BC Prognostic Anthropometric Parameters: A Five-Year Study

A. Perrone | A. M. Pintaudi | ... | M. A. Livrea
  • Special Issue
  • - Volume 2016
  • - Article ID 8026702
  • - Research Article

Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent Manner

Dominik Klumpp | Milan Misovic | ... | Stephan M. Huber
  • Special Issue
  • - Volume 2016
  • - Article ID 2536705
  • - Research Article

From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia

Claudia Bănescu | Mihaela Iancu | ... | Minodora Dobreanu
  • Special Issue
  • - Volume 2016
  • - Article ID 9875298
  • - Review Article

Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

Zhiqi Wang | Sai Li | ... | Deliang Cao
  • Special Issue
  • - Volume 2016
  • - Article ID 3907147
  • - Review Article

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

Marco Tafani | Luigi Sansone | ... | Matteo A. Russo
  • Special Issue
  • - Volume 2016
  • - Article ID 4148791
  • - Research Article

NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies

Hilal S. Khalil | Simon P. Langdon | ... | Yusuf Y. Deeni
  • Special Issue
  • - Volume 2016
  • - Article ID 8589318
  • - Review Article

Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers

Tao Zuo | Minghui Zhu | Wenming Xu
  • Special Issue
  • - Volume 2016
  • - Article ID 1716341
  • - Review Article

Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy

Alex Lyakhovich | Matilde E. Lleonart
  • Special Issue
  • - Volume 2016
  • - Article ID 6429812
  • - Research Article

Can Breast Tumors Affect the Oxidative Status of the Surrounding Environment? A Comparative Analysis among Cancerous Breast, Mammary Adjacent Tissue, and Plasma

C. Panis | V. J. Victorino | ... | R. Cecchini
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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