Oxidative Medicine and Cellular Longevity

Oxidative Stress and Cancer: Advances and Challenges


Status
Published

Lead Editor

1University of Texas MD Anderson Cancer Center, Houston, USA

2University of Mississippi Medical Center, Mississippi, USA

3Penn State Milton S. Hershey Medical Center, Pennsylvania, USA

4Institute of Bioresources and Sustainable Development (IBSD), Imphal, India


Oxidative Stress and Cancer: Advances and Challenges

Description

Cancer is a chronic disease caused by dysregulation of multiple genes and requires more than 25 years for development. Accumulating evidence suggests that reactive oxygen species (ROS) generated inside body under normal physiologic conditions are also critically involved in regulating tumor functions. Recent advancement in free radical biology and tumor biology suggests that ROS control numerous aspects of tumor development such as drug resistance, epithelial-to-mesenchymal transition, and cancer stemness. ROS have been demonstrated to regulate multistep process of tumor development including inflammation, transformation, survival, proliferation, invasion, angiogenesis, and metastasis by activating various oncogenic transcription factors. Paradoxically, ROS also control the expression of various tumor suppressor genes such as p53, Rb, and PTEN. Similarly, γ-radiation and various chemotherapeutic agents used to treat cancer mediate their effects through the production of ROS. This paradox provides a great challenge for researchers whose aim is to exploit ROS stress for the development of cancer therapies. Thus, a thorough assessment of current developments concerning role of ROS in tumor biology is required.

We invite authors around the world to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the role of ROS in tumor development. We are particularly interested in thought-provoking articles that provide an overview of existing concepts, novel findings, controversies, and challenges concerning the role of ROS in cancer development. Articles on future prospects of targeting ROS associated signaling molecules in cancer therapy are invited.

Potential topics include, but are not limited to:

  • ROS and drug resistance
  • ROS and multisteps of tumor development
  • ROS and cancer therapy
  • ROS and cancer stem cells
  • ROS and inflammation
  • ROS and cancer cell metabolism
  • ROS and dietary agents/nutraceuticals

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5845061
  • - Review Article

High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer

Aida Barreiro-Alonso | Mónica Lamas-Maceiras | ... | M. Esperanza Cerdán
  • Special Issue
  • - Volume 2016
  • - Article ID 1972793
  • - Research Article

Fisetin Modulates Antioxidant Enzymes and Inflammatory Factors to Inhibit Aflatoxin-B1 Induced Hepatocellular Carcinoma in Rats

Brajesh Kumar Maurya | Surendra Kumar Trigun
  • Special Issue
  • - Volume 2016
  • - Article ID 4941623
  • - Research Article

Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells

Ya-Qin Hou | Yao Yao | ... | Yu-Xin Li
  • Special Issue
  • - Volume 2016
  • - Article ID 3897250
  • - Research Article

The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species

Lun Zhang | Jiahui Li | ... | Xin Shen
  • Special Issue
  • - Volume 2016
  • - Article ID 2428153
  • - Review Article

Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance

In-geun Ryoo | Sang-hwan Lee | Mi-Kyoung Kwak
  • Special Issue
  • - Volume 2016
  • - Article ID 6719534
  • - Review Article

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results

Nuria Mut-Salud | Pablo Juan Álvarez | ... | Fernando Rodríguez-Serrano
  • Special Issue
  • - Volume 2016
  • - Article ID 3125989
  • - Research Article

Efficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish Population

J. Kabzinski | B. Mucha | ... | I. Majsterek
  • Special Issue
  • - Volume 2016
  • - Article ID 6815727
  • - Research Article

Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer

Liang Zong | Jiahui Li | ... | Hao Sun
  • Special Issue
  • - Volume 2016
  • - Article ID 6475624
  • - Review Article

Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies

Anna Maria Mileo | Stefania Miccadei
  • Special Issue
  • - Volume 2016
  • - Article ID 5710403
  • - Research Article

The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer

Nataliya V. Savina | Nataliya V. Nikitchenko | ... | Roza I. Goncharova
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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