Oxidative Medicine and Cellular Longevity

Neurodegeneration, Mitochondrial Dysfunction, and Oxidative Stress


Publishing date
03 May 2013
Status
Published
Submission deadline
14 Dec 2012

1Laboratory of Bioenergetics, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil

2Department of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland

3Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA


Neurodegeneration, Mitochondrial Dysfunction, and Oxidative Stress

Description

Mitochondria are intracellular organelles, which play a crucial role in energy metabolism. Most of cell energy is obtained through mitochondrial metabolic pathways, especially Krebs' cycle and electron transport chain which is the main site of reactive oxygen species production such as superoxide, hydrogen peroxide, and hydroxyl radicals. Brain is highly sensitive to oxidative stress due to its high oxygen consumption, iron and lipid contents, and low activity of antioxidant defenses. Thus, energy metabolism impairment and oxidative stress are important events that have been related to the pathogenesis of diseases affecting the central nervous system. Moreover, mitochondria are also key regulators of cell survival and death and play a central role in ageing. Further investigation in this subject will clarify several aspects in pathophysiology of neurodegenerative diseases.

We invite authors to submit original research and review articles that seek to refine the understanding of the role of mitochondrial dysfunction, energy metabolism impairment, and oxidative stress in pathophysiology of neurodegenerative diseases. Potential topics include, but are not limited to:

  • Alzheimer's, Parkinson's, and Huntington's disease and mitochondrial dysfunction and oxidative stress
  • Role of mitochondrial dysfunction/oxidative stress in pathophysiology of metabolic inherited disorders and psychiatric disorders
  • Pharmacological interactions of drugs used to treat neurodegenerative disorders with tissue and mitochondrial structure, biochemistry, and function
  • Drugs targeting the mitochondrion, especially antioxidants

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/oximed/nmdo/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 826046
  • - Editorial

Neurodegeneration, Mitochondrial Dysfunction, and Oxidative Stress

Emilio L. Streck | Grzegorz A. Czapski | Cleide Gonçalves da Silva
  • Special Issue
  • - Volume 2013
  • - Article ID 826143
  • - Research Article

Nitro-Oxidative Stress after Neuronal Ischemia Induces Protein Nitrotyrosination and Cell Death

Marta Tajes | Gerard ILL-Raga | ... | Francisco J. Muñoz
  • Special Issue
  • - Volume 2013
  • - Article ID 940603
  • - Review Article

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease

Siddhartha Mondragón-Rodríguez | George Perry | ... | Sylvain Williams
  • Special Issue
  • - Volume 2013
  • - Article ID 194546
  • - Review Article

Targeting Microglial KATP Channels to Treat Neurodegenerative Diseases: A Mitochondrial Issue

Manuel J. Rodríguez | Margot Martínez-Moreno | ... | Nicole Mahy
  • Special Issue
  • - Volume 2013
  • - Article ID 168039
  • - Review Article

Diabetic Neuropathy and Oxidative Stress: Therapeutic Perspectives

Asieh Hosseini | Mohammad Abdollahi
  • Special Issue
  • - Volume 2013
  • - Article ID 239854
  • - Review Article

Endoplasmic Reticulum Stress and Parkinson’s Disease: The Role of HRD1 in Averting Apoptosis in Neurodegenerative Disease

Tomohiro Omura | Masayuki Kaneko | ... | Yasuyuki Nomura
  • Special Issue
  • - Volume 2013
  • - Article ID 726954
  • - Review Article

Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures

Oddvar Myhre | Hans Utkilen | ... | Tim Hofer
  • Special Issue
  • - Volume 2013
  • - Article ID 607610
  • - Research Article

Neurotoxic Effects of trans-Glutaconic Acid in Rats

Patrícia F. Schuck | Estela N. B. Busanello | ... | Gustavo C. Ferreira
  • Special Issue
  • - Volume 2013
  • - Article ID 756989
  • - Review Article

Mitochondrial Mechanisms of Neuroglobin’s Neuroprotection

Zhanyang Yu | Jessica L. Poppe | Xiaoying Wang
  • Special Issue
  • - Volume 2013
  • - Article ID 194192
  • - Research Article

Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?

A. C. Fortes | A. A. C. Almeida | ... | M. F. R. Soares
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.