Oxidative Medicine and Cellular Longevity

Chemistry, Biology, and Pharmacology of Modulators of Oxidative Stress


Publishing date
01 Jun 2019
Status
Closed
Submission deadline
25 Jan 2019

Lead Editor

1Sapienza University of Rome, Rome, Italy

2University of Gdansk, Gdansk, Poland

3University of Lyon, Lyon, France

This issue is now closed for submissions.
More articles will be published in the near future.

Chemistry, Biology, and Pharmacology of Modulators of Oxidative Stress

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress (OS) is involved in the pathogenesis of many disorders and modulators of OS can be of value in their treatment. The mechanisms by which OS can be modulated, including the activation or inhibition of sirtuins and nuclear factor erythroid 2-related factor 2 (Nrf2), the master regulator of endogenous antioxidant enzymes, are currently of great interest. Unfortunately, it is known that antioxidant treatments failed in many clinical trials (https://clinicaltrials.gov/) and the reasons for that have not been fully elucidated to date. Novel approaches to redox therapies are necessary and the development of reliable biomarkers capable of predicting the clinical responses is crucial.

Furthermore, OS plays a crucial role in the physiology of various bacteria. It influences bacterial DNA replication, cell division, gene expression, protein modification, and their essential processes. Virulence of many bacteria is regulated, either positively or negatively, by OS conditions. Development of bacteriophages, viruses that infect bacterial cells, is also dependent on OS conditions and antioxidants’ action. This also concerns bacteriophages that determine virulence of bacterial strains by encoding strong toxins—such toxins are effectively produced only after prophage induction, a process stimulated by OS. Therefore, modulation of OS is crucial for understanding biological processes occurring in bacteria.

In this special issue, the main aspects of the modulation of OS will be examined.

Potential topics include but are not limited to the following:

  • Extraction, synthesis, and derivatization of modulators of OS, in particular concerning diseases of the central nervous system
  • Pharmacological applications of modulators of OS
  • Activators and inhibitors of Nrf2
  • Activators and inhibitors of sirtuin pathways
  • The role of OS in bacterial infections (mechanisms of regulation of OS response in bacterial cells, effects of OS on bacteriophage development, OS in host-bacteria interactions, use of modulators of OS in the treatment of infections, etc.)

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 5340290
  • - Research Article

IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice

Kengo Waga | Masaru Yamaguchi | ... | Ikuo Kashiwakura
  • Special Issue
  • - Volume 2019
  • - Article ID 7180284
  • - Research Article

Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression

Yeru Chen | Zhaohong Zheng | ... | Xiu Jun Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 7419249
  • - Research Article

Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice

Wei Chen | Xing-Xing Gao | ... | Yuan-Hua Chen
  • Special Issue
  • - Volume 2019
  • - Article ID 6181754
  • - Research Article

DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling

Xiang Zhou | Weiming Wang | ... | Gang Chen
  • Special Issue
  • - Volume 2019
  • - Article ID 8189079
  • - Research Article

lncRNA AK054386 Functions as a ceRNA to Sequester miR-199 and Induce Sustained Endoplasmic Reticulum Stress in Hepatic Reperfusion Injury

Binghua Dai | Liang Qiao | ... | Jiamei Yang
  • Special Issue
  • - Volume 2019
  • - Article ID 4608165
  • - Research Article

AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction

Fenxi Zhang | Zimei Dong | ... | Dezeng Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 4010764
  • - Research Article

LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis

Xiang Kong | Chong-xiao Liu | ... | Kun Lv
  • Special Issue
  • - Volume 2019
  • - Article ID 9372182
  • - Review Article

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

Natalia Robledinos-Antón | Raquel Fernández-Ginés | ... | Antonio Cuadrado
  • Special Issue
  • - Volume 2019
  • - Article ID 7092151
  • - Review Article

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

Sebastian Steven | Katie Frenis | ... | Andreas Daiber
  • Special Issue
  • - Volume 2019
  • - Article ID 8107265
  • - Review Article

Proresolving Lipid Mediators: Endogenous Modulators of Oxidative Stress

Alessandro Leuti | Mauro Maccarrone | Valerio Chiurchiù
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision80 days
Acceptance to publication47 days
CiteScore4.520
Impact Factor4.868
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