Oxidative Medicine and Cellular Longevity

Chemistry, Biology, and Pharmacology of Modulators of Oxidative Stress


Publishing date
01 Jun 2019
Status
Closed
Submission deadline
25 Jan 2019

Lead Editor

1Sapienza University of Rome, Rome, Italy

2University of Gdansk, Gdansk, Poland

3University of Lyon, Lyon, France

This issue is now closed for submissions.
More articles will be published in the near future.

Chemistry, Biology, and Pharmacology of Modulators of Oxidative Stress

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress (OS) is involved in the pathogenesis of many disorders and modulators of OS can be of value in their treatment. The mechanisms by which OS can be modulated, including the activation or inhibition of sirtuins and nuclear factor erythroid 2-related factor 2 (Nrf2), the master regulator of endogenous antioxidant enzymes, are currently of great interest. Unfortunately, it is known that antioxidant treatments failed in many clinical trials (https://clinicaltrials.gov/) and the reasons for that have not been fully elucidated to date. Novel approaches to redox therapies are necessary and the development of reliable biomarkers capable of predicting the clinical responses is crucial.

Furthermore, OS plays a crucial role in the physiology of various bacteria. It influences bacterial DNA replication, cell division, gene expression, protein modification, and their essential processes. Virulence of many bacteria is regulated, either positively or negatively, by OS conditions. Development of bacteriophages, viruses that infect bacterial cells, is also dependent on OS conditions and antioxidants’ action. This also concerns bacteriophages that determine virulence of bacterial strains by encoding strong toxins—such toxins are effectively produced only after prophage induction, a process stimulated by OS. Therefore, modulation of OS is crucial for understanding biological processes occurring in bacteria.

In this special issue, the main aspects of the modulation of OS will be examined.

Potential topics include but are not limited to the following:

  • Extraction, synthesis, and derivatization of modulators of OS, in particular concerning diseases of the central nervous system
  • Pharmacological applications of modulators of OS
  • Activators and inhibitors of Nrf2
  • Activators and inhibitors of sirtuin pathways
  • The role of OS in bacterial infections (mechanisms of regulation of OS response in bacterial cells, effects of OS on bacteriophage development, OS in host-bacteria interactions, use of modulators of OS in the treatment of infections, etc.)

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 7450151
  • - Research Article

TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5)

Mengmeng Xu | Yanbei Zhang | ... | Feng Li
  • Special Issue
  • - Volume 2019
  • - Article ID 1826303
  • - Research Article

Potential of Mitochondria-Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic β-cells

Lydie Plecitá-Hlavatá | Hana Engstová | ... | Petr Ježek
  • Special Issue
  • - Volume 2019
  • - Article ID 5953685
  • - Review Article

Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications

Elisabetta Bigagli | Maura Lodovici
  • Special Issue
  • - Volume 2019
  • - Article ID 5028181
  • - Review Article

Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease

Vladan P. Bajic | Christophe Van Neste | ... | Esma R. Isenovic
  • Special Issue
  • - Volume 2019
  • - Article ID 5459862
  • - Research Article

Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume

Umer Farooq | Yanjun Pan | ... | Jianhua Qi
  • Special Issue
  • - Volume 2019
  • - Article ID 7857082
  • - Research Article

Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal Ischemia/Reperfusion

Xin Fan | Juan Du | ... | Jun Zhou
  • Special Issue
  • - Volume 2019
  • - Article ID 8526083
  • - Research Article

Waterpipe Smoke Exposure Triggers Lung Injury and Functional Decline in Mice: Protective Effect of Gum Arabic

Abderrahim Nemmar | Suhail Al-Salam | ... | Badreldin H. Ali
  • Special Issue
  • - Volume 2019
  • - Article ID 5461617
  • - Research Article

Early Kidney Damage Markers after Deferasirox Treatment in Patients with Thalassemia Major: A Case-Control Study

Hamidreza Badeli | Adel Baghersalimi | ... | Ilaria Peluso
  • Special Issue
  • - Volume 2019
  • - Article ID 7283639
  • - Research Article

MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury

Sifei Yu | Lei Xie | ... | Yu Liang
  • Special Issue
  • - Volume 2019
  • - Article ID 5897675
  • - Research Article

Antistress Effects of San-Huang-Xie-Xin Decoction on Restraint-Stressed Mice Revealed by 1H NMR-Based Metabolomics and Biochemistry Analysis

Wei Peng | Huan Du | ... | Gang Fan
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate49%
Submission to final decision75 days
Acceptance to publication38 days
CiteScore4.520
Impact Factor4.868
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