Oxidative Medicine and Cellular Longevity

Redox Biology of Infection and Consequent Disease


Publishing date
01 Aug 2019
Status
Published
Submission deadline
05 Apr 2019

1Riga Stradins University, Stockholm, Sweden

2Cancer Research Centre of Lyon, Lyon, France

3Russian Academy of Sciences, Moscow, Russia


Redox Biology of Infection and Consequent Disease

Description

Bacteria and viruses account for a wide spectrum of communicable diseases. According to WHO statistics, they are responsible for 16% of deaths worldwide. Furthermore, they are responsible for severe morbidities, as after the initial infection, hundreds of millions develop chronic pathologies such as chronic hepatitis, cardiovascular, neurodegenerative, and autoimmune diseases. Some microbes are directly oncogenic, and some cause chronic inflammation predisposing to cancer, contributing to non-communicable disease-caused deaths.

Research carried out during the last two decades demonstrated that many of these infections trigger the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which has previously been shown for viral hepatitis B, C, and D, human immunodeficiency virus (HIV-1), influenza A, Epstein-Barr virus, respiratory syncytial, rhino-, corona-, herpes, and papilloma viruses. There is increasing data on a role for oxidative stress in salmonellosis, tuberculosis, helicobacter, and pseudomonas infections. Enhanced ROS/RNS production has been implicated in diseases such as fibrosis, cirrhosis, metabolic dysfunction, lung tissue injury, and epithelial barrier dysfunction, which in turn increase the susceptibility to secondary infections. Oxidative stress induced in HIV infection contributes to neurodegenerative complications.

Significant progress has been achieved in this field during the past years. However, little is known about the interplay between the pathogens and oxidative stress reaction(s) of the host. In this special issue we would like to invite authors to submit original research and review articles on redox biology of infections and concomitant infection-associated pathologies. We also encourage submission of articles outside the field of infectious diseases that address any questions that have been neglected by microbiologists and that can promote research on the redox biology of infection.

Potential topics include but are not limited to the following:

  • Mechanisms by which infections enhance ROS/RNS production
  • Influence of ROS/RNS on pathogen replication/reproduction
  • Effect of viruses and bacteria on the antioxidant systems of the host
  • Role of ROS/RNS in the development of inflammation, neoplastic transformation, fibrosis, metabolic dysfunctions, and other pathogen-associated pathologies
  • Redox-dependent posttranslational modifications of proteins of pathogens and host cell
  • ROS/RNS and chemotherapy
  • ROS/RNS as the organic part of the host immune defense against the microbes
  • Reactive carbon and chlorine species as well as hydrogen sulfide in infection and consequent disease
  • Identification of the redox switches employed by the microbes

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 5829521
  • - Editorial

Redox Biology of Infection and Consequent Disease

Maria G. Isaguliants | Birke Bartosch | Alexander V. Ivanov
  • Special Issue
  • - Volume 2019
  • - Article ID 6016278
  • - Research Article

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

Ekaterina Bayurova | Juris Jansons | ... | Maria Isaguliants
  • Special Issue
  • - Volume 2019
  • - Article ID 1607903
  • - Research Article

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

Cristian Cezar Login | Ioana Bâldea | ... | Şoimiţa Suciu
  • Special Issue
  • - Volume 2019
  • - Article ID 4957878
  • - Research Article

Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches

Xiaotian Fu | Dongmei Chen | ... | Liqian Zhu
  • Special Issue
  • - Volume 2019
  • - Article ID 1297484
  • - Research Article

Structure-Guided Approach to Identify Potential Inhibitors of Large Envelope Protein to Prevent Hepatitis B Virus Infection

Mahboubeh Mehmankhah | Ruchika Bhat | ... | Syed Naqui Kazim
  • Special Issue
  • - Volume 2019
  • - Article ID 3196140
  • - Research Article

Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

Marina K. Kukhanova | Vera L. Tunitskaya | ... | Alexander V. Ivanov
  • Special Issue
  • - Volume 2019
  • - Article ID 1409582
  • - Review Article

Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis

Zhenzhen Zhang | Liang Rong | Yi-Ping Li
  • Special Issue
  • - Volume 2019
  • - Article ID 6175804
  • - Review Article

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

Anastasiya V. Snezhkina | Anna V. Kudryavtseva | ... | Alexey A. Dmitriev
  • Special Issue
  • - Volume 2019
  • - Article ID 2082561
  • - Research Article

Therapeutic Effect of the Mitochondria-Targeted Antioxidant SkQ1 on the Culture Model of Multiple Sclerosis

Elena K. Fetisova | Maria S. Muntyan | ... | Boris V. Chernyak
  • Special Issue
  • - Volume 2019
  • - Article ID 9451671
  • - Research Article

TRPV1 Contributes to Cerebral Malaria Severity and Mortality by Regulating Brain Inflammation

Domingos Magno Santos Pereira | Simone Aparecida Teixeira | ... | Elizabeth Soares Fernandes
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate42%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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