Oxidative Medicine and Cellular Longevity

Oxidative Stress in Retinal Diseases


Status
Published

Lead Editor

1Mie University Graduate, Tsu, Japan

2Gifu Pharmaceutical University, Gifu, Japan

3Mie University, Tsu, Japan

4Yonsei University, Seoul, Republic of Korea

5Santen Pharmaceutical Co. Ltd., Osaka, Japan


Oxidative Stress in Retinal Diseases

Description

The retina is exposed to chronic oxidative stress through several mechanisms, including constant exposure to light and reactive oxygen species generated by visual signal transduction pathways due to high oxygen consumption, oxidization of polyunsaturated fatty acids, and phagocytosis of photoreceptor cells. In the healthy state, all cell types in the retina are able to maintain homeostasis under conditions of oxidative stress. However, when the balance between pro- and antioxidative signaling is compromised, excessive oxidative stress induces dysregulation of functional networks and deleterious changes that result in visual impairment. Age-related macular degeneration, diabetic retinopathy, and glaucoma are leading causes of visual impairment. Owing to a combination of lifestyle changes such as eating a high-fat diet and decrease in physical activity and extended life expectancy, an increasing number of people are at risk for retinal diseases, and the resulting economic burden imposed on health care systems is increasing accordingly.

We invite authors to contribute original research articles and reviews focusing on the role of oxidative stress in retinal diseases. This special issue will stimulate further efforts to understand retinal diseases at the systems level, with the hope of finding new preconditioning and therapeutic strategies to prevent or treat retinal pathologies.

Potential topics include but are not limited to the following:

  • Basic molecular and cellular mechanisms underlying oxidative stress in retinal diseases
  • Recent discoveries on the roles of oxidative stress in retinal diseases
  • Dietary therapies for oxidative stress in retinal diseases
  • New preventive and therapeutic strategies focused on oxidative stress in retinal diseases
  • Clinical trials of retinal diseases: importance of oxidative stress in disease alleviation
  • New in vitro and in vivo models to test and understand oxidative stress in retinal diseases

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4076518
  • - Editorial

Oxidative Stress in Retinal Diseases

Yuhei Nishimura | Hideaki Hara | ... | Takeshi Matsugi
  • Special Issue
  • - Volume 2017
  • - Article ID 4128061
  • - Research Article

Spermidine Oxidation-Mediated Degeneration of Retinal Pigment Epithelium in Rats

Koji Ohashi | Masaaki Kageyama | ... | Masatsugu Nakamura
  • Special Issue
  • - Volume 2017
  • - Article ID 2817252
  • - Review Article

Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis

Atsuko Kimura | Kazuhiko Namekata | ... | Takayuki Harada
  • Special Issue
  • - Volume 2017
  • - Article ID 9702820
  • - Review Article

Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy

Cheng Li | Xiao Miao | ... | Jian Sun
  • Special Issue
  • - Volume 2017
  • - Article ID 9548767
  • - Research Article

Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration

Toshiyuki Matsuura | Kei Takayama | ... | Hiroko Terasaki
  • Special Issue
  • - Volume 2017
  • - Article ID 3187594
  • - Review Article

Sirtuins Expression and Their Role in Retinal Diseases

Sankarathi Balaiya | Khaled K. Abu-Amero | ... | Kakarla V. Chalam
  • Special Issue
  • - Volume 2017
  • - Article ID 9208489
  • - Review Article

Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

Tomomi Masuda | Masamitsu Shimazawa | Hideaki Hara
  • Special Issue
  • - Volume 2016
  • - Article ID 2370252
  • - Review Article

Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases

Yuhei Nishimura | Hideaki Hara
  • Special Issue
  • - Volume 2016
  • - Article ID 7469326
  • - Review Article

Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases

Yasuhiro Nakagami
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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