Oxidative Stress in Retinal Diseases
1Mie University Graduate, Tsu, Japan
2Gifu Pharmaceutical University, Gifu, Japan
3Mie University, Tsu, Japan
4Yonsei University, Seoul, Republic of Korea
5Santen Pharmaceutical Co. Ltd., Osaka, Japan
Oxidative Stress in Retinal Diseases
Description
The retina is exposed to chronic oxidative stress through several mechanisms, including constant exposure to light and reactive oxygen species generated by visual signal transduction pathways due to high oxygen consumption, oxidization of polyunsaturated fatty acids, and phagocytosis of photoreceptor cells. In the healthy state, all cell types in the retina are able to maintain homeostasis under conditions of oxidative stress. However, when the balance between pro- and antioxidative signaling is compromised, excessive oxidative stress induces dysregulation of functional networks and deleterious changes that result in visual impairment. Age-related macular degeneration, diabetic retinopathy, and glaucoma are leading causes of visual impairment. Owing to a combination of lifestyle changes such as eating a high-fat diet and decrease in physical activity and extended life expectancy, an increasing number of people are at risk for retinal diseases, and the resulting economic burden imposed on health care systems is increasing accordingly.
We invite authors to contribute original research articles and reviews focusing on the role of oxidative stress in retinal diseases. This special issue will stimulate further efforts to understand retinal diseases at the systems level, with the hope of finding new preconditioning and therapeutic strategies to prevent or treat retinal pathologies.
Potential topics include but are not limited to the following:
- Basic molecular and cellular mechanisms underlying oxidative stress in retinal diseases
- Recent discoveries on the roles of oxidative stress in retinal diseases
- Dietary therapies for oxidative stress in retinal diseases
- New preventive and therapeutic strategies focused on oxidative stress in retinal diseases
- Clinical trials of retinal diseases: importance of oxidative stress in disease alleviation
- New in vitro and in vivo models to test and understand oxidative stress in retinal diseases