Oxidative Medicine and Cellular Longevity

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects 2018


Publishing date
01 Jan 2019
Status
Published
Submission deadline
31 Aug 2018

Lead Editor

1Sapienza University of Rome, Rome, Italy

2Akdeniz University, Antalya, Turkey

3University of Missouri, Kansas City, USA


Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects 2018

Description

Reactive oxygen (ROS) and nitrogen (RNS) species are generated as byproducts of normal cellular metabolic activities and have been implicated in the pathogenesis of a variety of diseases. Disruption of normal cellular homeostasis by redox signaling may result in chronic infections, inflammatory disorders, cardiovascular and neurodegenerative diseases, and cancer.

Notwithstanding that the multiple roles of oxidative stress in human normal biology and pathology have been intensely discussed over the last half century, the problem is still far beyond our full comprehension. Thus, in a comparatively short history of oxidative medicine, the roles of free radicals and antioxidants have been entirely redefined. Some negative actions of free radicals and ROS in human biology and pathology, widely recognized two to three decades ago, have been subsequently transformed into positive ones, in the appreciation of their essential impact in the intracellular signaling on the organism's defense against biotic and abiotic stresses. On the other hand, the great hope that direct antioxidants could be the panacea resolving practically all health problems has vanished, due to the growing number of inconclusive or negative data from epidemiological and clinical studies.

The current state of uncertainty regarding feasibility of antioxidant therapy is partly due to methodological pitfalls in the drug development and delivery, the limited and often overlooked knowledge regarding the antioxidant metabolism and their interaction with physiologically important molecular/cellular processes in the organism, and the lack of correlations between biological markers of oxidative stress and clinical outcomes. Modulation of oxidative stress is important to develop new therapies to manage a variety of conditions for which current therapies are not effective.

The main aim of this special issue is to address different pharmaceutical and pharmacological aspects of research related to modulation of oxidative stress. In particular, contributions focused on the following issues will be particularly welcome.

Potential topics include but are not limited to the following:

  • Synthesis and derivatization of antioxidant compounds with potential pharmacological applications to modulate their antioxidant properties and bioavailability
  • Mechanism of action of antioxidant compounds with special attention to the Nrf2/ARE signaling pathway
  • Pharmacokinetics, metabolic pathways, and antioxidant activity of metabolites
  • Optimization of delivery systems
  • In vitro and in vivo studies on the pharmacological activity of antioxidants
  • Epidemiological and clinical studies on the efficacy of antioxidant therapies
  • Relevant biological markers to assess in vivo antioxidant/prooxidant action and its correlation with clinical efficacy

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 6380473
  • - Editorial

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects 2018

Robert E. Smith | Tomris Ozben | Luciano Saso
  • Special Issue
  • - Volume 2019
  • - Article ID 3276958
  • - Research Article

The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus

Víctor Manuel Mendoza-Núñez | Beatriz Isabel García-Martínez | ... | Vicente Jesús Hernández-Abad
  • Special Issue
  • - Volume 2019
  • - Article ID 8745376
  • - Research Article

Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium

Nataša Popović | Vesna Stojiljković | ... | Snežana B. Pajović
  • Special Issue
  • - Volume 2019
  • - Article ID 2069250
  • - Research Article

Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent

Dušan S. Dimić | Zoran S. Marković | ... | Jasmina M. Dimitrić Marković
  • Special Issue
  • - Volume 2019
  • - Article ID 6452390
  • - Research Article

Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures

Simona Anticoli | Donatella Amatore | ... | Anna Ruggieri
  • Special Issue
  • - Volume 2019
  • - Article ID 6026902
  • - Research Article

Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice

Jakub Šuk | Jana Jašprová | ... | Libor Vítek
  • Special Issue
  • - Volume 2019
  • - Article ID 7090534
  • - Review Article

Role of Nrf2 and Its Activators in Respiratory Diseases

Qinmei Liu | Yun Gao | Xinxin Ci
  • Special Issue
  • - Volume 2018
  • - Article ID 6069150
  • - Research Article

Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression

Bai-liu Ya | Qian Liu | ... | Bo Bai
  • Special Issue
  • - Volume 2018
  • - Article ID 2518676
  • - Research Article

C60 Fullerene Prevents Restraint Stress-Induced Oxidative Disorders in Rat Tissues: Possible Involvement of the Nrf2/ARE-Antioxidant Pathway

Olga O. Gonchar | Andriy V. Maznychenko | ... | Alexander I. Kostyukov
  • Special Issue
  • - Volume 2018
  • - Article ID 6430601
  • - Research Article

Oxidative Stress in Autistic Children Alters Erythrocyte Shape in the Absence of Quantitative Protein Alterations and of Loss of Membrane Phospholipid Asymmetry

Alessandra Bolotta | Michela Battistelli | ... | Provvidenza Maria Abruzzo
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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