Oxidative Medicine and Cellular Longevity

Natural Products in the Prevention and Treatment of ROS-induced Diseases


Publishing date
01 Apr 2021
Status
Closed
Submission deadline
11 Dec 2020

Lead Editor

1The University of Hong Kong, Hong Kong

2Shanghai Ocean University, Shanghai, China

3Dalian Polytechnic University, Dalian, China

4University of Massachusetts, Amherst, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Natural Products in the Prevention and Treatment of ROS-induced Diseases

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress is generated when the balance between ROS and antioxidant levels as well as antioxidant enzymes existing endogenously in the body is disrupted, resulting in potential cell damage. In addition, reactive carbonyl species (RCS) produced during lipid peroxidation and Maillard reaction, and advanced glycation end products (AGEs) generated in physiological systems with high glucose concentration have been shown to have a strong relationship with the formation of ROS. Multiple lines of evidence from both laboratory and clinical studies have linked ROS to pathophysiology associated with various diseases such as inflammation, neurodegenerative diseases, cardiovascular diseases, and all stages of carcinogenesis.

Antioxidant defense has been considered as an efficient way to prevent the development of certain ROS-mediated diseases. Many natural products have been reported to inhibit RCS/AGEs formation and modulate signaling pathways, gene and microRNA expression, and epigenetic mechanisms in the prevention or management of ROS-mediated diseases. Further information is required to decipher the underlying mechanisms of how natural products and drug candidates, independently or in combination with each other, influence these processes.

Contributions to this Special Issue may cover all research aspects related to the field of oxidative stress and mechanisms of action of natural products and synthetic drugs in ROS-induced chronic diseases, including but not limited to inflammation, neurodegenerative diseases, cardiovascular diseases and cancer. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • Inhibitory mechanism of natural products on RCS/AGEs formation in vitro and in vivo
  • Effects of natural antioxidant compounds on lipid peroxidation in vitro and in vivo
  • Natural antioxidants to modulate oxidative stress and/or reverse diseases
  • Relationship between autophagy modulation and ROS-induced chronic diseases
  • Anti-oxidative and anti-inflammatory effects and mechanisms of natural products
  • The use of mitochondria-targeted natural antioxidants as therapeutic strategies for disease intervention
  • The role of oxidative stress and inflammation and their interplay with autophagy, as well as their modulation by natural products and synthetic drugs

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 8820406
  • - Review Article

Natural Products for Neurodegeneration: Regulating Neurotrophic Signals

Md Sahab Uddin | Abdullah Al Mamun | ... | Mohamed M. Abdel-Daim
  • Special Issue
  • - Volume 2021
  • - Article ID 6635552
  • - Research Article

Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects

Muhammad Ikram | Min Gi Jo | ... | Myeong Ok Kim
  • Special Issue
  • - Volume 2021
  • - Article ID 6692628
  • - Research Article

Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and In Vitro Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer

Akbar Pasha | Divya Vishambhar Kumbhakar | ... | Smita C. Pawar
  • Special Issue
  • - Volume 2021
  • - Article ID 8887716
  • - Research Article

Linalool Alleviates Aβ42-Induced Neurodegeneration via Suppressing ROS Production and Inflammation in Fly and Rat Models of Alzheimer’s Disease

Chunyu Yuan | Myeongcheol Shin | ... | Kyoung Sang Cho
  • Special Issue
  • - Volume 2021
  • - Article ID 6685282
  • - Research Article

Zi Shen Decoction Inhibits Growth and Metastasis of Lung Cancer via Regulating the AKT/GSK-3β/β-Catenin Pathway

Yanxia Ma | Yu Liu | ... | Lei Bi
  • Special Issue
  • - Volume 2021
  • - Article ID 6661514
  • - Review Article

The Role of Antioxidants in the Management of Obsessive-Compulsive Disorder

Fatemeh Baratzadeh | Sepideh Elyasi | ... | Amirhossein Sahebkar
  • Special Issue
  • - Volume 2021
  • - Article ID 6621644
  • - Review Article

Plant-Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Hang-Yu Li | Ren-You Gan | ... | Hua-Bin Li
  • Special Issue
  • - Volume 2021
  • - Article ID 8833467
  • - Research Article

Antioxidative Capacity of Liver- and Adipose-Derived Mesenchymal Stem Cell-Conditioned Media and Their Applicability in Treatment of Type 2 Diabetic Rats

Mohamed M. Elshemy | Medhat Asem | ... | Ahmed Nabil
  • Special Issue
  • - Volume 2021
  • - Article ID 6627355
  • - Review Article

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Dan-Dan Zhou | Min Luo | ... | Hua-Bin Li
  • Special Issue
  • - Volume 2021
  • - Article ID 8891445
  • - Research Article

Euryops arabicus Promotes Healing of Excised Wounds in Rat Skin: Emphasis on Its Collagen-Enhancing, Antioxidant, and Anti-Inflammatory Activities

Ahmed Abdel-Lateff | Ashraf B. Abdel-Naim | ... | Usama A. Fahmy
Oxidative Medicine and Cellular Longevity
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Acceptance rate48%
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Acceptance to publication37 days
CiteScore7.900
Impact Factor6.543
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.