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Neurodegeneration, Neurogenesis, and Oxidative Stress

Call for Papers

Oxidative stress is implicated in the pathophysiology of a wide variety of neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, amyotrophic lateral sclerosis, and stroke. Neural stem cells persist in the adult brain and continue to produce neurons throughout life. However, neurogenesis is impaired in inflammation-associated diseases by mechanisms poorly understood. In addition, the contribution of neurogenesis impairment to disease progression is not clear. Over the last years, stem cell technologies have made this system become an increasingly attractive target for the development of neurodegenerative disease therapies. Thus, further investigation in this subject will clarify several aspects of the implication of oxidative stress and inflammation in neurodegeneration and neurogenesis and contribute to the development of future therapies for neurodegenerative diseases.

We invite authors to submit original research and review articles that seek to refine the understanding of the role of oxidative and nitrosative stress, calcium, mitochondrial functions, and inflammation in the pathophysiology of neurodegenerative diseases and neurogenesis. Potential topics include, but are not limited to:

  • Research in the function of mitochondria, reactive oxygen species, and nitric oxide in neurogenesis and neuron survival
  • Advances in the role of oxidative stress in neurodegeneration
  • Role of inflammation in neurodegeneration and neurogenesis
  • Role of microglia in the neurogenic zones of the brain
  • Research on neuronal and glial proteins involved in neurodegeneration or neurogenesis
  • Recent developments in stem cell therapies for neurodegenerative diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 24 May 2013
First Round of ReviewsFriday, 19 July 2013
Publication DateFriday, 13 September 2013

Lead Guest Editor

  • Renata Santos, Development of the Nervous System Laboratory, Ecole Normale Supérieure, IBENS, 46 rue d'Ulm, 75230 Paris Cedex 05, France

Guest Editors

  • Carmen Ruiz de Almodovar, Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
  • Anne-Laure Bulteau, Mitochondria, Bioenergetics, Metabolism and Signaling Laboratory, Cochin Institute, 24 Rue du Faubourg Saint-Jacques, 75014 Paris, France
  • Cláudio M. Gomes, Protein Biochemistry, Folding and Stability Laboratory, Instituto Tecnologia Quimica e Biologica (ITQB), UNL, Avenida da República E.A.N., 2784-505 Oeiras, Portugal