Oxidative Medicine and Cellular Longevity

ROS and Oxidative Stress in Stem Cells


Status
Published

1University of Oslo, Oslo, Norway

2City University of Hong Kong, Kowloon, Hong Kong

3National Yang-Ming University, Taipei, Taiwan

4Silesian University of Technology, Gliwice, Poland


ROS and Oxidative Stress in Stem Cells

Description

Reactive oxygen species (ROS) are well known to be implicated in various important processes including cell signaling, regulation of homeostasis, or induction of cell death.

Oxidative stress resulting from increased ROS production and impaired free radical scavenging systems can cause severe damage to biological macromolecules affecting cell proliferation and causing genomic instability. Although ROS are involved in a wide range of cellular processes, a limited number of studies have examined the generation and function of ROS in stem cells. It is known that reactive oxygen species may enhance differentiation of stem cells and facilitate reprogramming into induced pluripotent stem cells (iPSC), but on the other hand they are also associated with malignant transformation or premature aging. Stem cells have been also shown to possess defective DNA repair machinery which upon extensive oxidative stress may have serious consequences for cells.

Since stem cells (and especially iPSC) are considered as a promising tool in regeneration medicine, it is crucial to know and better understand all processes related to ROS to prevent potential generation of mutations causing genomic instability and to avoid unwanted ROS driven differentiation. Thus, the mechanisms by which genomic integrity of stem cells is maintained under oxidative stress and the role of ROS should be elucidated until stem cells finally find their place in clinical applications.

We would like to invite authors to contribute original research articles as well as review articles that will explore and help to understand the various roles of ROS in stem cell biology. Particular interest will be given to papers describing the molecular mechanisms of action by which ROS modulate stemness, affect differentiation, and alter reprogramming of somatic cells into iPSC. We are also interested in articles that explore aspects of ROS and oxidative stress in cancer stem cells.

Potential topics include but are not limited to the following:

  • Redox regulation in stem cells
  • Role of reactive oxygen species in cellular reprogramming
  • Role of reactive oxygen species in stem cell differentiation and stemness maintenance
  • Role of reactive oxygen species in normal and malignant hematopoiesis
  • Role of reactive oxygen species in cell cycle regulation of stem cells
  • Effects of oxidative stress on (cancer) stem cells biology
  • DNA damage and DNA repair in (cancer) stem cells
  • Mitochondrial dysfunctions in (cancer) stem cells
  • Role of reactive oxygen species in cell death and senescence of stem cells

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 5047168
  • - Editorial

ROS and Oxidative Stress in Stem Cells

Artur Cieślar-Pobuda | Jianbo Yue | ... | Yau-Huei Wei
  • Special Issue
  • - Volume 2017
  • - Article ID 9515809
  • - Research Article

Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response

V. A. Sergeeva | E. S. Ershova | ... | S. V. Kostyuk
  • Special Issue
  • - Volume 2017
  • - Article ID 4386947
  • - Research Article

Hypoxia Downregulates MAPK/ERK but Not STAT3 Signaling in ROS-Dependent and HIF-1-Independent Manners in Mouse Embryonic Stem Cells

Jan Kučera | Julie Netušilová | ... | Jiří Pacherník
  • Special Issue
  • - Volume 2017
  • - Article ID 4745252
  • - Research Article

Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency

D. Sainz de la Maza | A. Moratilla | ... | M. P. De Miguel
  • Special Issue
  • - Volume 2017
  • - Article ID 9420539
  • - Review Article

NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells

Magdalena Skonieczna | Tomasz Hejmo | ... | Rafal J. Buldak
  • Special Issue
  • - Volume 2017
  • - Article ID 5691215
  • - Research Article

Mitochondrial Transfer from Wharton’s Jelly Mesenchymal Stem Cell to MERRF Cybrid Reduces Oxidative Stress and Improves Mitochondrial Bioenergetics

Yao-Chung Chuang | Chia-Wei Liou | ... | Tsu-Kung Lin
  • Special Issue
  • - Volume 2017
  • - Article ID 8510805
  • - Research Article

Enhancement of Mitochondrial Transfer by Antioxidants in Human Mesenchymal Stem Cells

Chia-Jung Li | Po-Kong Chen | ... | Cheng-Yoong Pang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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