The liver is the second largest organ in the body with a major contribution to the regulation of systemic metabolism. This places the liver at the centre of an extraordinary biomedical interest due to the increased prevalence worldwide of liver associated-diseases and due to the complex genetic and proteomic background behind these conditions. These circumstances generate a fertile ground for the application of complex multiomics approaches. Liver diseases can be caused by viruses, drugs, poisons, chemical agents, or excess of alcohol. Moreover, fatty liver induced by metabolic diseases can potentially progress toward oxidative hepatocellular damage, inflammation, and fibrosis up to cirrhosis and hepatocellular carcinoma. A better molecular characterization of inherited or acquired liver diseases may have profound clinical implications.

The purpose of this special issue is to gather information on the biochemical and molecular mechanisms underlying different liver pathologies with particular attention to those with metabolic origin with the aim of identifying therapeutic strategies for their treatment and new biomarkers of disease. In particular, we will focus on the possible association between oxidative metabolism and liver disease onset and progression, oxidative metabolism and inflammation, and the significance of antioxidant agents as an effective tool for the prevention of liver disease. For this purpose, we invite authors to contribute original research articles as well as review articles.

Potential topics include but are not limited to the following:

• Studies on oxidative stress in liver disease
• Metabolic syndrome and liver modifications
• Metabolic changes in liver cancer
• Natural products for liver diseases
• Autophagy in liver diseases
• Antioxidant agent in the treatment of liver diseases
• Nutritional interventions in liver steatosis