Oxidative Medicine and Cellular Longevity

How Dietary Natural Molecules, Redox Biology, Bioenergetics and Immune Function Impact Health and Disease


Publishing date
01 Dec 2020
Status
Closed
Submission deadline
24 Jul 2020

1Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

2Centro Universitário Metodista, Porto Alegre, Brazil

3State University of New York at Plattsburgh, Plattsburgh, USA

4KIIT University, Bhubaneswar, India

This issue is now closed for submissions.
More articles will be published in the near future.

How Dietary Natural Molecules, Redox Biology, Bioenergetics and Immune Function Impact Health and Disease

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Natural molecules present in the human diet may improve life quality by exerting antioxidant, anti-inflammatory, antitumor, and antimicrobial actions. Moreover, it has been demonstrated that natural molecules, mainly from plant origin, can modulate mitochondria-related bioenergetics. The mechanism of action includes the regulation of specific gene expression, as well as activation of non-genomic pathways. Moreover, epigenetic mechanisms are also responsible for mediating the effects promoted by natural molecules. Preventing mitochondrial dysfunction would be a critical strategy to promote cytoprotection, since these organelles are central players in both redox biology and bioenergetics homeostasis in mammalian cells.

Moreover, natural molecules are also involved in the modulation of inflammation, as assessed in several in vitro and in vivo experimental models. In some cases, the link between redox and bioenergetics impairments and inflammation is central in both onset and progression of disease. In fact, mitochondrial dysfunction has been described to be involved in neurodegenerative disorders (such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease) as well as in cardiovascular diseases (such as stroke, hypertension, and vascular diseases). In some cases, the link between impairment of bioenergetics and inflammation is central in both onset and progression of those conditions. Finally, despite great advances in investigating the effects of natural molecules at cellular level, poor bioavailability may limit the benefits of this natural molecules administered orally as a supplement or as part of our diet. Therefore, strategies focusing in improving the delivery of natural molecules to targeted cells as well as increasing their chemical stability are of great interest in the growing field of nanotechnology.

In this Special Issue, we are interested in manuscripts that demonstrate the effects of dietary bioactive molecules in the redox biology, bioenergetics, and immune functions in animal cells and that were obtained from in vitro, ex vivo, and/or in vivo experimental models. Reviews dealing with the effects of dietary bioactive molecules on these aspects may also be submitted.

Potential topics include but are not limited to the following:

  • The effects of dietary natural molecules on the redox biology of animal cells.
  • The impact of dietary natural molecules on the integrity of organelles, such as mitochondria, endoplasmic reticulum, and lysosomes.
  • Alterations in bioenergetics resulting from the treatment with dietary natural molecules.
  • The ability of dietary natural molecules to modulate cell signaling pathways and gene expression in the redox, bioenergetics, and immune function contexts.
  • The effects of dietary natural molecules in experimental models of diseases.
  • Nanotechnology-related strategies utilized to improve the bioavailability of dietary natural molecules to the different mammalian cell types.

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Oxidative Medicine and Cellular Longevity
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