Oxidative Medicine and Cellular Longevity

Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods 2019


Publishing date
01 Jul 2019
Status
Closed
Submission deadline
22 Feb 2019

Lead Editor

1Council for Agricultural Research and Economics, Rome, Italy

2Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain

3Biofortis-Mérieux NutriSciences, Saint Herblain, France

4Sapienza University of Rome, Rome, Italy

This issue is now closed for submissions.
More articles will be published in the near future.

Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods 2019

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress is defined as the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidant defense favoring the former. Enhanced oxidative stress occurs when ROS formation is increased by an array of exogenous and endogenous factors, for example, smoking, exposure to pollution, unhealthy diet, and chronic/low grade inflammation, when the antioxidant defense capacity is compromised, or both. Enhanced oxidative stress has been appreciated for the contribution to the pathogenesis of noncommunicable diseases (i.e., cardiovascular disease, metabolic syndrome, cancer, and brain disorders). In addition to attacking susceptible macromolecules, protein, DNA, and lipid, ROS modulate the expression of genes that are regulated by nuclear factor-erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB). For example, Nrf2 stimulates the transcription of antioxidant enzymes through the antioxidant responsive elements (ARE) and the activation of NF-κB elicits the gene expression of inflammatory cytokines. Therefore, there is a concerted modulation of Nrf2 and NF-κB in inflammation and oxidative stress. In this context, many nutraceuticals exert their anti-inflammatory and antioxidant effects through the inhibition of NF-κB and the activation of Nrf2, respectively.

Further, one of the most promising areas for the development of functional foods lies in modulation of the immune system by the use of probiotics, prebiotics, and synbiotics. Particularly, research examining the interactions occurring between probiotics, prebiotics, and nutraceuticals at the levels of the gut microbiota and of the Gut Associated Lymphoid Tissue (GALT) is emerging. These interactions are relevant in the design of nutraceuticals and functional food for the prevention of noncommunicable diseases associated with dysbiosis, oxidative stress, and chronic low-grade inflammation.

To this special issue, we invite investigators to contribute original research articles based on both preclinical and clinical data and comprehensive reviews aiming to evaluate the antioxidant and anti-inflammatory activities of nutraceuticals and functional foods, as well as the functional quality assessment of both natural and industrially processed foods.

Potential topics include but are not limited to the following:

  • Human, animal, or in vitro studies in relation to oxidative stress and inflammation: the effects of nutraceuticals, natural, and industrially processed foods, probiotics, prebiotics, and synbiotics
  • Molecular mechanisms of antioxidant and anti-inflammatory effects of nutraceuticals
  • Recent insights into the relationship between probiotics, prebiotics, and nutraceuticals in the area of molecular and cellular mechanisms, genetic mechanisms, and nutrition and immune modulation
  • Human, animal, or in vitro studies evaluating the effects of food, functional foods, and nutraceuticals on the host-microbiota (microbiome) interactions
  • In vivo effects of food, functional foods, and nutraceuticals on the markers of oxidative stress and inflammation
  • Characterization of novel functional foods, natural products, and phytochemical extracts in relation to oxidative stress and inflammation

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 5620484
  • - Research Article

Antioxidant and Antigenotoxic Potential of Infundibulicybe geotropa Mushroom Collected from Northwestern Turkey

Mustafa Sevindik | Hasan Akgul | ... | Nady Braidy
  • Special Issue
  • - Volume 2019
  • - Article ID 4168380
  • - Research Article

Green Tea Prevents NAFLD by Modulation of miR-34a and miR-194 Expression in a High-Fat Diet Mouse Model

L. F. Torres | B. Cogliati | R. Otton
  • Special Issue
  • - Volume 2019
  • - Article ID 6183965
  • - Review Article

Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds

Rasool Nasiri Kalmarzi | Seyyed Nima Naleini | ... | Wesam Kooti
  • Special Issue
  • - Volume 2019
  • - Article ID 9481390
  • - Research Article

Heat-Resistant Aphanizomenon flos-aquae (AFA) Extract (Klamin®) as a Functional Ingredient in Food Strategy for Prevention of Oxidative Stress

D. Nuzzo | M. Contardi | ... | M. Di Carlo
  • Special Issue
  • - Volume 2019
  • - Article ID 2716870
  • - Review Article

Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

Christine A. Houghton
  • Special Issue
  • - Volume 2019
  • - Article ID 9480945
  • - Research Article

Indigo Naturalis Suppresses Colonic Oxidative Stress and Th1/Th17 Responses of DSS-Induced Colitis in Mice

Hai-tao Xiao | Jiao Peng | ... | Zhao-xiang Bian
  • Special Issue
  • - Volume 2019
  • - Article ID 3492767
  • - Research Article

Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome

Roxana Cojocariu | Alin Ciobica | ... | Radu Lefter
  • Special Issue
  • - Volume 2019
  • - Article ID 8918914
  • - Research Article

Sargassum fusiforme Fucoidan SP2 Extends the Lifespan of Drosophila melanogaster by Upregulating the Nrf2-Mediated Antioxidant Signaling Pathway

Ya Zhang | Man Xu | ... | Peichao Chen
  • Special Issue
  • - Volume 2019
  • - Article ID 8431057
  • - Research Article

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Magdalena Górnicka | Anna Ciecierska | ... | Agata Wawrzyniak
  • Special Issue
  • - Volume 2019
  • - Article ID 8407206
  • - Research Article

Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats

Yaping Yang | Ciyan Xu | ... | Tsz Kin Ng
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision78 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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