Oxidative Medicine and Cellular Longevity

Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods 2019


Publishing date
01 Jul 2019
Status
Published
Submission deadline
22 Feb 2019

Lead Editor

1Council for Agricultural Research and Economics, Rome, Italy

2Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain

3Biofortis-Mérieux NutriSciences, Saint Herblain, France

4Sapienza University of Rome, Rome, Italy


Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods 2019

Description

Oxidative stress is defined as the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidant defense favoring the former. Enhanced oxidative stress occurs when ROS formation is increased by an array of exogenous and endogenous factors, for example, smoking, exposure to pollution, unhealthy diet, and chronic/low grade inflammation, when the antioxidant defense capacity is compromised, or both. Enhanced oxidative stress has been appreciated for the contribution to the pathogenesis of noncommunicable diseases (i.e., cardiovascular disease, metabolic syndrome, cancer, and brain disorders). In addition to attacking susceptible macromolecules, protein, DNA, and lipid, ROS modulate the expression of genes that are regulated by nuclear factor-erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB). For example, Nrf2 stimulates the transcription of antioxidant enzymes through the antioxidant responsive elements (ARE) and the activation of NF-κB elicits the gene expression of inflammatory cytokines. Therefore, there is a concerted modulation of Nrf2 and NF-κB in inflammation and oxidative stress. In this context, many nutraceuticals exert their anti-inflammatory and antioxidant effects through the inhibition of NF-κB and the activation of Nrf2, respectively.

Further, one of the most promising areas for the development of functional foods lies in modulation of the immune system by the use of probiotics, prebiotics, and synbiotics. Particularly, research examining the interactions occurring between probiotics, prebiotics, and nutraceuticals at the levels of the gut microbiota and of the Gut Associated Lymphoid Tissue (GALT) is emerging. These interactions are relevant in the design of nutraceuticals and functional food for the prevention of noncommunicable diseases associated with dysbiosis, oxidative stress, and chronic low-grade inflammation.

To this special issue, we invite investigators to contribute original research articles based on both preclinical and clinical data and comprehensive reviews aiming to evaluate the antioxidant and anti-inflammatory activities of nutraceuticals and functional foods, as well as the functional quality assessment of both natural and industrially processed foods.

Potential topics include but are not limited to the following:

  • Human, animal, or in vitro studies in relation to oxidative stress and inflammation: the effects of nutraceuticals, natural, and industrially processed foods, probiotics, prebiotics, and synbiotics
  • Molecular mechanisms of antioxidant and anti-inflammatory effects of nutraceuticals
  • Recent insights into the relationship between probiotics, prebiotics, and nutraceuticals in the area of molecular and cellular mechanisms, genetic mechanisms, and nutrition and immune modulation
  • Human, animal, or in vitro studies evaluating the effects of food, functional foods, and nutraceuticals on the host-microbiota (microbiome) interactions
  • In vivo effects of food, functional foods, and nutraceuticals on the markers of oxidative stress and inflammation
  • Characterization of novel functional foods, natural products, and phytochemical extracts in relation to oxidative stress and inflammation

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 8431057
  • - Research Article

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Magdalena Górnicka | Anna Ciecierska | ... | Agata Wawrzyniak
  • Special Issue
  • - Volume 2019
  • - Article ID 8407206
  • - Research Article

Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats

Yaping Yang | Ciyan Xu | ... | Tsz Kin Ng
  • Special Issue
  • - Volume 2019
  • - Article ID 6764756
  • - Research Article

The Ameliorative Effects of the Ethyl Acetate Extract of Salicornia europaea L. and Its Bioactive Candidate, Irilin B, on LPS-Induced Microglial Inflammation and MPTP-Intoxicated PD-Like Mouse Model

Joonsoo Kim | Govindarajan Karthivashan | ... | Dong-Kug Choi
  • Special Issue
  • - Volume 2019
  • - Article ID 8194804
  • - Research Article

Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD

Wei-jie Lv | Cui Liu | ... | Shi-ning Guo
  • Special Issue
  • - Volume 2019
  • - Article ID 7384193
  • - Research Article

Neutrophil-to-Lymphocyte Ratio, Mediterranean Diet, and Bone Health in Coeliac Disease Patients: A Pilot Study

Francesca Palmacci | Elisabetta Toti | ... | Maura Palmery
  • Special Issue
  • - Volume 2019
  • - Article ID 3187972
  • - Research Article

SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway

Kun-Lin Chen | Lian Li | ... | Gen-Lin Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 6714103
  • - Research Article

S. Giovanni Varieties (Pyrus communis L.): Antioxidant Properties and Phytochemical Characteristics

Elena Azzini | Giuseppe Maiani | ... | Angela Polito
  • Special Issue
  • - Volume 2019
  • - Article ID 5049643
  • - Research Article

In Vivo Pharmacological and Anti-inflammatory Evaluation of Xerophyte Plantago sempervirens Crantz

Anca D. Farcaș | Augustin C. Moț | ... | Marcel Pârvu
  • Special Issue
  • - Volume 2019
  • - Article ID 4739450
  • - Review Article

Traditional Uses, Bioactive Constituents, Biological Functions, and Safety Properties of Oviductus ranae as Functional Foods in China

Yang Zhang | Yifei Wang | ... | Hongli Zhou
  • Special Issue
  • - Volume 2019
  • - Article ID 5176090
  • - Research Article

Active Constituent in the Ethyl Acetate Extract Fraction of Terminalia bellirica Fruit Exhibits Antioxidation, Antifibrosis, and Proapoptosis Capabilities In Vitro

Yuxin Chen | Gao Zhou | ... | Youwei Wang
Oxidative Medicine and Cellular Longevity
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Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.900
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.