Oxidative Medicine and Cellular Longevity

Neuropsychiatric Disturbances and Diabetes Mellitus: The Role of Oxidative Stress


Publishing date
01 Mar 2019
Status
Published
Submission deadline
09 Nov 2018

Lead Editor

1University of Catania, Sicily, Italy

2University of Texas, Texas, USA


Neuropsychiatric Disturbances and Diabetes Mellitus: The Role of Oxidative Stress

Description

Oxidative stress plays a fundamental role in the pathogenesis and progression of type 1 and type 2 diabetes mellitus. In addition, it represents the molecular basis shared by diabetes and other comorbid disorders.

From a neurological point of view, diabetes can be associated with cognitive impairment, represents a risk factor for stroke, and worsens poststroke outcomes. The diabetic changes in the redox status account at least in part for the neurological manifestations of diabetes. In fact, hypo- and hyperglycaemic episodes determine oxidative insults in the brain and cause further damage after brain injury. In addition, oxidative stress is crucially involved in the occurrence of diabetic neuropathy and leads to an accelerated brain aging, thus increasing the risk for neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases).

From a psychiatric point of view, both behavioural and biochemical aspects explain the link between diabetes and psyche. For example, diabetes and depression share the same risk factors, such as poor diet and physical inactivity, as well as oxidative and nitrosative stress. The gut-brain axis could account for the comorbidity between depression and medical disorders, including diabetes. In addition, if unhealthy dietary habits are frequent among patients suffering from schizophrenia, the latter is characterized by high levels of advanced glycation end products (AGEs) that could favour the occurrence of oxidative stress-related diseases, such as diabetes. On the other hand, psychiatric drugs (antidepressants, antipsychotics, and mood stabilizers) can determine metabolic disturbances, thus favouring the occurrence of diabetes.

In this special issue, we are inviting researchers to contribute with original research articles as well as review articles that seek to address the role of oxidative stress in the occurrence, progression, and management of neuropsychiatric disturbances in diabetes mellitus.

Potential topics include but are not limited to the following:

  • Oxidative stress in diabetes and metabolic syndrome
  • Oxidative stress and psychiatric drugs-induced metabolic disturbances
  • Oxidative stress as a link between diabetes and neurological disorders
  • Oxidative stress as a link between diabetes and psychiatric disorders
  • Oxidative stress and gut-brain axis

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 5698132
  • - Editorial

Neuropsychiatric Disturbances and Diabetes Mellitus: The Role of Oxidative Stress

Maria Luca | Maurizio Di Mauro | George Perry
  • Special Issue
  • - Volume 2019
  • - Article ID 3206542
  • - Research Article

Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects

Ran Li | Yuan Liu | ... | Chun-guang Qiu
  • Special Issue
  • - Volume 2019
  • - Article ID 8267234
  • - Review Article

Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases

Rosa Vona | Lucrezia Gambardella | ... | Donatella Pietraforte
  • Special Issue
  • - Volume 2019
  • - Article ID 4730539
  • - Review Article

Gut Microbiota in Alzheimer’s Disease, Depression, and Type 2 Diabetes Mellitus: The Role of Oxidative Stress

Maria Luca | Maurizio Di Mauro | ... | Antonina Luca
  • Special Issue
  • - Volume 2019
  • - Article ID 8637970
  • - Review Article

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Gislaine Z. Réus | Anelise S. Carlessi | ... | João Quevedo
  • Special Issue
  • - Volume 2019
  • - Article ID 9089035
  • - Research Article

The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition

Warin Ohnon | Jintanaporn Wattanathorn | ... | Terdthai Tong-un
  • Special Issue
  • - Volume 2018
  • - Article ID 8930374
  • - Research Article

Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress

Hong-Xin Cui | Ya-Nan Hu | ... | Ke Yuan
  • Special Issue
  • - Volume 2018
  • - Article ID 2406594
  • - Review Article

Oxidative Stress and the Microbiota-Gut-Brain Axis

Laura Dumitrescu | Iulia Popescu-Olaru | ... | Bogdan Ovidiu Popescu
  • Special Issue
  • - Volume 2018
  • - Article ID 8616194
  • - Research Article

Effects of Irbesartan Pretreatment on Pancreatic β-Cell Apoptosis in STZ-Induced Acute Prediabetic Mice

Cuihong Chen | Li Li | ... | Xinghuan Liang
  • Special Issue
  • - Volume 2018
  • - Article ID 1752940
  • - Research Article

Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes

Angelina Passaro | Giovanni Battista Vigna | ... | Carlo Cervellati
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision78 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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