Oxidative Medicine and Cellular Longevity

Oxidative Stress and Pigmentation Disorders: Mechanisms, Signaling Pathways, and Therapeutics


Publishing date
01 May 2022
Status
Closed
Submission deadline
24 Dec 2021

Lead Editor

1Fudan University, Shanghai, China

2Medical University of Vienna, Vienna, Austria

3Fourth Military Medical University, Xi'an, China

4Shanghai Jiao Tong University School of Medicine, Shanghai, China

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress and Pigmentation Disorders: Mechanisms, Signaling Pathways, and Therapeutics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Pigmentation disorders can result from dysregulated changes in the number of melanocytes (MCs) or the function of melanocytes, such as abnormalities in melanin production, distribution, transport to the surrounding keratinocytes, or melanin degradation. Melanin synthesis is an energy-consuming process, which tends to form a pro-oxidative state and produces a large amount of reactive oxygen species (ROS) in MCs, therefore melanocytes are vulnerable to oxidative stress. Moreover, MCs are exposed to chronic oxidative stress with the irradiation of ultraviolet (UV), pollution, or other harmful factors.

When the balance between the pro- and antioxidant systems is broken, oxidative stress will cause DNA damage, biological metabolism dysregulation, and signaling pathways changes in MCs. In addition, the aberrant ROS accumulation in keratinocytes and fibroblasts could also contribute to pigmentation disorders by affecting MCs. Additionally, many herbal products and organic compounds with antioxidant functions have been found to alleviate pigmentation disorders.

In this Special Issue, we expect to explore the role of oxidative stress in pigmentation disorders and invite researchers to contribute original research or review articles aiming to discuss the oxidative stress-associated mechanisms, signaling pathways, and corresponding therapeutics in the pathogenesis and treatment of pigmentation disorders.

Potential topics include but are not limited to the following:

  • The role of oxidative stress in pigmentation disorders: hyperpigmentation disorders including melasma, post-inflammatory hyperpigmentation (PIH), UV-induced pigmentation, etc.; hypopigmentation disorders including vitiligo, halo nevus, chemical leukoderma, dyspigmented hypertrophic scar, etc.; age-related pigmentation disorders, including seborrheic keratosis (SK), age-related macular degeneration (AMD), etc.; pigment cell tumors, especially malignant melanoma
  • Basic molecular and cellular mechanisms focused on oxidative stress in pigmentation disorders
  • The application of antioxidants or new therapeutics underlying oxidative stress in pigmentation disorders
  • In vivo and in vitro studies focused on the mechanisms or therapeutics underlying oxidative stress in pigmentation disorders

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 1821780
  • - Review Article

Research Progress on Targeted Antioxidant Therapy and Vitiligo

Jingzhan Zhang | Wen Hu | ... | Xiaojing Kang
  • Special Issue
  • - Volume 2022
  • - Article ID 9897442
  • - Research Article

Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition

Yongyi Xie | Zile Chen | Zhouwei Wu
  • Special Issue
  • - Volume 2022
  • - Article ID 2994558
  • - Research Article

The Current Status of Antioxidants in the Treatment of Vitiligo in China

Ying Zhou | Manal Khan | ... | Qinghai Zeng
  • Special Issue
  • - Volume 2022
  • - Article ID 6732972
  • - Research Article

Occludin Promotes Adhesion of CD8+ T Cells and Melanocytes in Vitiligo via the HIF-1α Signaling Pathway

Puyu Zou | Yangfan Xiao | ... | Rong Xiao
  • Special Issue
  • - Volume 2022
  • - Article ID 1856830
  • - Research Article

sPmel17 Secreted by Ultraviolet B-Exposed Melanocytes Alters the Intercellular Adhesion of Keratinocytes

Shuang-Hai Hu | Shan Jiang | ... | Tie-Chi Lei
  • Special Issue
  • - Volume 2022
  • - Article ID 8498472
  • - Review Article

The Role of Oxidative Stress in the Pathogenesis of Vitiligo: A Culprit for Melanocyte Death

Yijie Xuan | Yiwen Yang | ... | Chengfeng Zhang
  • Special Issue
  • - Volume 2022
  • - Article ID 8796735
  • - Review Article

The Promising Role of Chemokines in Vitiligo: From Oxidative Stress to the Autoimmune Response

Shan He | Jinhua Xu | Jinfeng Wu
  • Special Issue
  • - Volume 2022
  • - Article ID 7881717
  • - Review Article

Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders

Xiaoxue Xing | Yanjun Dan | ... | Leihong Xiang
  • Special Issue
  • - Volume 2021
  • - Article ID 1608586
  • - Research Article

Folic Acid Protects Melanocytes from Oxidative Stress via Activation of Nrf2 and Inhibition of HMGB1

Pengran Du | Shaolong Zhang | ... | Weigang Zhang
  • Special Issue
  • - Volume 2021
  • - Article ID 7617839
  • - Research Article

The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress

Jun Tian | Yaojun Wang | ... | Qiang Li
Oxidative Medicine and Cellular Longevity
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Acceptance rate33%
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.