Oxidative Medicine and Cellular Longevity

Harmful and Beneficial Role of ROS 2017


Status
Published

Lead Editor

1Universita degli Studi di Napoli Federico II, Naples, Italy

2Eastern Kentucky University, Richmond, USA

3Universitat de València, Valencia, Spain


Harmful and Beneficial Role of ROS 2017

Description

It is long known that reactive oxygen species (ROS) are an unavoidable by-product of oxygen metabolism and their cellular concentrations are determined by the balance between their rates of production and their rates of clearance by various antioxidant compounds and enzymes. For a decade or two after the discovery of their presence in biological materials, ROS were thought to cause exclusively toxic effects and were associated with various pathologies. Indeed, when ROS overwhelm the cellular antioxidant defense system, oxidative stress occurs, which results in oxidative damage of nucleic acids, proteins, and lipids. This potentially harmful effect of ROS has been implicated in carcinogenesis, neurodegeneration, atherosclerosis, diabetes, and aging. However, in time the view has been formulated that the presence of ROS in cells indicates that ROS production was evolutionarily selected in order to perform some useful roles.

This view was supported by increasing evidence that while prolonged exposure to high ROS concentrations may lead, through oxidative damage of cellular constituents, to various disorders, low ROS concentrations exert their effects rather through regulation of cell signaling cascades. Indeed, ROS have important functions in cellular signaling as participants and modifiers of signaling pathways, essential for the proper development and proliferation of cells, may have mitogenic effects, and can mimic and amplify the action of growth factors. Moreover, it is apparent that biological specificity of ROS action is achieved through the amount, duration, and localization of ROS production. To date, although major ROS-sensitive signal transduction pathways involved in adaptive responses have been shown, a lot remains to be understood about their mutual interaction and the modifications during ageing and some disease states.

Because of the relevance of such topics, it appears appropriate to summarize some of the main recent advances on ROS production and their harmful and beneficial role in the living organisms, mainly focusing attention on their impact on health, diseases, and ageing.

We invite authors to submit original researches and review articles that seek to refine the aforementioned topics.

Potential topics include but are not limited to the following:

  • Positive feedback loop in ROS production
  • Interaction among cellular sources of ROS production
  • Hormetic effects of ROS
  • Oxidative and antioxidative stress
  • New insight into the relationship between oxidative stress and ageing
  • Role of oxidative stress in neurodegenerative and cardiovascular diseases
  • Signaling pathways of ROS action

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5943635
  • - Editorial

Harmful and Beneficial Role of ROS 2017

Sergio Di Meo | Tanea T. Reed | ... | Victor M. Victor
  • Special Issue
  • - Volume 2018
  • - Article ID 1941285
  • - Review Article

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Ana L. Santos | Sanchari Sinha | Ariel B. Lindner
  • Special Issue
  • - Volume 2018
  • - Article ID 8587475
  • - Research Article

ROS-Induced DNA Damage Associates with Abundance of Mitochondrial DNA in White Blood Cells of the Untreated Schizophrenic Patients

I. V. Chestkov | E. M. Jestkova | ... | S. V. Kostyuk
  • Special Issue
  • - Volume 2017
  • - Article ID 6341671
  • - Research Article

Cadmium-Induced Oxidative Stress Impairs Glycemic Control in Adolescents

Gabriele Pizzino | Natasha Irrera | ... | Domenica Altavilla
  • Special Issue
  • - Volume 2017
  • - Article ID 8156594
  • - Research Article

Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension

Martina Cebova | Jana Klimentova | ... | Olga Pechanova
  • Special Issue
  • - Volume 2017
  • - Article ID 9718615
  • - Research Article

The Role of Oxidative Stress in Decreased Acetylcholinesterase Activity at the Neuromuscular Junction of the Diaphragm during Sepsis

Hua Liu | Jin Wu | ... | Shi-tong Li
  • Special Issue
  • - Volume 2017
  • - Article ID 4015874
  • - Review Article

Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage

Bettina P. Mihalas | Kate A. Redgrove | ... | Brett Nixon
  • Special Issue
  • - Volume 2017
  • - Article ID 7265238
  • - Review Article

Oxidative Stress and Endometriosis: A Systematic Review of the Literature

Gennaro Scutiero | Piergiorgio Iannone | ... | Luigi Nappi
  • Special Issue
  • - Volume 2017
  • - Article ID 8475125
  • - Review Article

Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action

Thierry Léveillard | Najate Aït-Ali
  • Special Issue
  • - Volume 2017
  • - Article ID 2181942
  • - Research Article

Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation

Natalia Cichoń | Piotr Czarny | ... | Joanna Saluk-Bijak
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision78 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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