Oxidative Medicine and Cellular Longevity

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects 2017


Status
Published

Lead Editor

1Sapienza University of Rome, Rome, Italy

2Centre for Innovative Biotechnological Research, Moscow, Russia

3Rudjer Boskovic Institute, Zagreb, Croatia


Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects 2017

Description

Reactive oxygen (ROS) and nitrogen (RNS) species are generated as by-products of normal cellular metabolic activities and have been implicated in the pathogenesis of a variety of diseases. Disruption of normal cellular homeostasis by redox signaling may result in chronic infections, inflammatory disorders, cardiovascular and neurodegenerative diseases, and cancer.

Notwithstanding that the multiple roles of oxidative stress in human normal biology and pathology have been intensely discussed over last half century, the problem is still far beyond our full comprehension. Thus, in a comparatively short history of oxidative medicine, the roles of free radicals and antioxidants have been entirely redefined. Some negative actions of free radicals and ROS in human biology and pathology, widely recognized two to three decades ago, have been subsequently transformed into positive ones, in the appreciation of their essential impact in the intracellular signaling on the organism's defense against biotic and abiotic stresses. On the other hand, the great hope that direct antioxidants could be the panacea resolving practically all health problems has vanished, due to the growing number of inconclusive or negative data from epidemiological and clinical studies.

The current state of uncertainty regarding feasibility of antioxidant therapy is partly due to methodological pitfalls in the drug development and delivery, the limited and often overlooked knowledge regarding the antioxidant metabolism and their interaction with physiologically important molecular/cellular processes in the organism, and the lack of correlations between biological markers of oxidative stress and clinical outcomes. Modulation of oxidative stress is important to develop new therapies to manage a variety of conditions for which current therapies are not effective.

The main aim of this special issue is to address different pharmaceutical and pharmacological aspects of research related to modulation of oxidative stress. In particular, contributions focused on the following issues will be particularly welcome.

Potential topics include but are not limited to the following:

  • Synthesis and derivatization of antioxidant compounds with potential pharmacological applications to modulate their antioxidant properties and bioavailability
  • Mechanism of action of antioxidant compounds with special attention to the Nrf2/ARE signaling pathway
  • Pharmacokinetics, metabolic pathways, and antioxidant activity of metabolites
  • Optimization of delivery systems
  • In vitro and in vivo studies on the pharmacological activity of antioxidants
  • Epidemiological and clinical studies on the efficacy of antioxidant therapies
  • Relevant biological markers to assess in vivo antioxidant/prooxidant action and its correlation with clinical efficacy

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4802824
  • - Editorial

Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects 2017

Luciano Saso | Liudmila Korkina | Neven Zarkovic
  • Special Issue
  • - Volume 2017
  • - Article ID 5061639
  • - Research Article

Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite

M. R. Ricciardi | R. Licchetta | ... | A. Tafuri
  • Special Issue
  • - Volume 2017
  • - Article ID 2873030
  • - Research Article

Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer

Juan Carlos Cantón-Romero | Alejandra Guillermina Miranda-Díaz | ... | Adolfo Daniel Rodríguez-Carrizalez
  • Special Issue
  • - Volume 2017
  • - Article ID 1740317
  • - Research Article

Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation

Guangbing Wei | Yunhua Wu | ... | Xuqi Li
  • Special Issue
  • - Volume 2017
  • - Article ID 1675230
  • - Review Article

Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells

Leonid Minasyan | Parameswaran G. Sreekumar | ... | Ram Kannan
  • Special Issue
  • - Volume 2017
  • - Article ID 7295319
  • - Research Article

REGγ Contributes to Regulation of Hemoglobin and Hemoglobin δ Subunit

Qiuhong Zuo | Shanshan Cheng | ... | Xiaotao Li
  • Special Issue
  • - Volume 2017
  • - Article ID 5187102
  • - Research Article

Neuroprotective and Memory-Enhancing Effect of the Combined Extract of Purple Waxy Corn Cob and Pandan in Ovariectomized Rats

Woranan Kirisattayakul | Jintanaporn Wattanathorn | ... | Kamol Lertrat
  • Special Issue
  • - Volume 2017
  • - Article ID 5205471
  • - Research Article

Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System

Maya Ben Yehuda Greenwald | Marina Frušić-Zlotkin | ... | Ron Kohen
  • Special Issue
  • - Volume 2017
  • - Article ID 3034245
  • - Review Article

Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress

Manuela Graziani | Paolo Sarti | ... | Luciano Saso
  • Special Issue
  • - Volume 2017
  • - Article ID 9808520
  • - Research Article

Cytoprotective Mechanisms Mediated by Polyphenols from Chilean Native Berries against Free Radical-Induced Damage on AGS Cells

Felipe Ávila | Cristina Theoduloz | ... | Guillermo Schmeda-Hirschmann
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate42%
Submission to final decision55 days
Acceptance to publication39 days
CiteScore7.300
Impact Factor5.076
 Submit

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.