Oxidative Medicine and Cellular Longevity

Neuroprotection in Neurodegenerative Disease: From Basic Science to Clinical Applications


Status
Published

1Federal University of Pará, Belém, Brazil

2Aston University, Birmingham, UK

3Federal University of Santa Catarina, Florianópolis, Brazil


Neuroprotection in Neurodegenerative Disease: From Basic Science to Clinical Applications

Description

Neurodegeneration is a multifactorial and complex process, and several mechanisms have been pointed to be involved in the pathogenesis of neurodegenerative disorders, such as increased oxidative/nitrosative stress, mitochondrial dysfunction, neuroinflammation, apoptosis, protein misfolding/aggregation, and glutamatergic excitotoxicity. Thus, we seek to explore, based on basic and clinical studies, novel neuroprotective mechanisms focused on antioxidant, anti-inflammatory, antiapoptotic, and glutamate receptor antagonists, modulation of neurotrophic factors, and others.

We cordially invite authors to submit original research and review articles to elucidate the knowledge from basic science to clinical applications of molecular and cellular mechanisms of neuroprotection associating the role of oxidative, immune, and inflammatory responses from neurodegenerative diseases. In addition, the ultimate goal of these papers is to understand potential therapeutic targets and preventive strategies focusing on neurodegenerative diseases.

Potential topics include, but are not limited to:

  • Major neurodegenerative diseases: aetiologies and pathologies, roles of oxidative stress, and mitochondrial dysfunction
  • Novel therapeutic interventions: immune, inflammatory, and antioxidant aspects of neurodegenerative diseases; influence of the blood-brain barrier in drug penetration
  • Neuroprotection strategies: molecular and cellular mechanisms; importance of oxidative stress relative to other mechanisms
  • Other therapeutic neuroprotective strategies: epigenetic processes, impact of natural products, pre- and postconditioning, and role of maladaptive neural responses; role of the blood-brain barrier
  • In vitro and in vivo models of CNS neuroprotection, relevance to human
  • Clinical trials of neuroprotective initiatives; importance of oxidative stress in disease alleviation

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2949102
  • - Editorial

Neuroprotection in Neurodegenerative Disease: From Basic Science to Clinical Applications

Marta C. Monteiro | Michael D. Coleman | ... | Cristiane S. F. Maia
  • Special Issue
  • - Volume 2017
  • - Article ID 4504925
  • - Research Article

Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes

J. Bento-Torres | L. L. Sobral | ... | Cristovam Wanderley Picanço Diniz
  • Special Issue
  • - Volume 2016
  • - Article ID 3173564
  • - Research Article

Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies

Rafael R. Lima | Luana N. S. Santana | ... | Walace Gomes-Leal
  • Special Issue
  • - Volume 2016
  • - Article ID 3974648
  • - Research Article

Virus Infections on Prion Diseased Mice Exacerbate Inflammatory Microglial Response

Nara Lins | Luiz Mourão | ... | Cristovam Wanderley Picanço-Diniz
  • Special Issue
  • - Volume 2016
  • - Article ID 8309031
  • - Research Article

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol

Roshni Thakkar | Ruimin Wang | ... | Darrell Brann
  • Special Issue
  • - Volume 2016
  • - Article ID 2735347
  • - Research Article

Hydrogen Sulfide Regulates the [Ca2+]i Level in the Primary Medullary Neurons

Xiaoni Liu | Nana Zhang | ... | Ning Lu
  • Special Issue
  • - Volume 2016
  • - Article ID 3472032
  • - Review Article

Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms

Josiel Mileno Mack | Marissa Giovanna Schamne | ... | Rui Daniel Prediger
  • Special Issue
  • - Volume 2016
  • - Article ID 2906953
  • - Research Article

Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis

Cinthia Cristina Sousa de Menezes da Silveira | Luanna Melo Pereira Fernandes | ... | Cristiane Socorro Ferraz Maia
  • Special Issue
  • - Volume 2016
  • - Article ID 4135135
  • - Research Article

In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species

Daniel Załuski | Rafał Kuźniewski
  • Special Issue
  • - Volume 2016
  • - Article ID 4196572
  • - Research Article

HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway

Yanlan Chen | Wen Huang | ... | Xiaoting Zhou
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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