Oxidative Medicine and Cellular Longevity

Oxidative Stress and Mitochondrial Damage in Neurodegenerative Diseases: From Molecular Mechanisms to Targeted Therapies


Publishing date
01 Aug 2019
Status
Closed
Submission deadline
05 Apr 2019

1University of Florence, Florence, Italy

2Universität Bonn, Bonn, Germany

3Universitat de València, Valencia, Spain

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress and Mitochondrial Damage in Neurodegenerative Diseases: From Molecular Mechanisms to Targeted Therapies

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). These neurodegenerative disorders are normally characterized by progressive loss of neuronal cells and compromised motor or cognitive functions. It has been shown that neuronal cells are particularly vulnerable to oxidative damage due to their high polyunsaturated fatty acid content in membranes, high oxygen consumption, and weak antioxidant defense. Alteration (or negative regulation) of intracellular redox state leads to the overproduction of reactive oxygen species (ROS), which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain complexes, alter membrane permeability, influence Ca2+ homeostasis, and challenge mitochondrial quality control and mitochondrial defense systems. All these changes are implicated in the development of neurodegenerative diseases, mediating or amplifying neuronal dysfunction and triggering neurodegeneration. However, the exact molecular pathogenesis of neurodegeneration related to the disruption of redox balance remains unclear. The progress in the development of neuroprotective therapies has been hindered, because it is difficult to define the right targets for treatment and what should be considered as an efficient neuroprotective agent (or medicament). Therefore, in the past years, the attention was focused on researches about pharmacological targets that could protect neurons against oxidative stress. Novel antioxidants have shown great potential in mediating disease phenotypes and several potential drugs have been screened in in vitro and in vivo models of neurodegenerative diseases. Although the outcomes from these studies are not yet translated in benefit for the patients and disappointing results were obtained from numerous clinical trials, the area of targeting oxidative stress in neurodegenerative diseases could be of great interest for further research.

We invite investigators to contribute to this special issue with original research articles as well as reviews addressing the role of oxidative stress in neurodegeneration. We encourage submissions of manuscripts aimed at elucidating the molecular and cellular mechanisms linking the disruption of intracellular redox status with the development of neurodegenerative diseases. We are particularly interested in articles covering the identification of new relevant targets regulated by redox signaling as well as new potential antioxidant therapy or alternative ways to prevent or control free radicals generation.

Potential topics include but are not limited to the following:

  • Updates about the role of mitochondrial dysfunction, ER stress, and oxidative stress in the onset and propagation of neurodegenerative diseases
  • Mitochondrial dysfunction in aging-related neurodegenerative diseases: causes or consequences
  • Recent advances in antioxidant prevention in pharmacology and treatments against mitochondrial failure of neurodegenerative diseases
  • Oxidative stress and its impact on neurons and glia
  • Experimental models to study the role of oxidative stress and mitochondrial dysfunction in neurodegeneration and neurodegenerative diseases
  • Potential role of mitochondrial damage in the pathogenesis of neurodegenerative disorders
  • Oxidative stress and mitochondrial failure in neurodegeneration

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 5797512
  • - Research Article

Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson’s Disease

Hye-Sun Lim | Joong-Sun Kim | ... | Gunhyuk Park
  • Special Issue
  • - Volume 2019
  • - Article ID 4174803
  • - Research Article

Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson’s Disease Model

Jeongsu Han | Soo Jeong Kim | ... | Gi Ryang Kweon
  • Special Issue
  • - Volume 2019
  • - Article ID 4578462
  • - Review Article

Current Progress of Mitochondrial Quality Control Pathways Underlying the Pathogenesis of Parkinson’s Disease

Xue Jiang | Tao Jin | ... | Ying Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 5410657
  • - Review Article

Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator

Jordan H. Cater | Mark R. Wilson | Amy R. Wyatt
  • Special Issue
  • - Volume 2019
  • - Article ID 9693726
  • - Research Article

Nickel Enhances Zinc-Induced Neuronal Cell Death by Priming the Endoplasmic Reticulum Stress Response

Ken-ichiro Tanaka | Misato Kasai | ... | Masahiro Kawahara
  • Special Issue
  • - Volume 2019
  • - Article ID 1712323
  • - Research Article

Aberrations in Oxidative Stress Markers in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

Zihao Wang | Zhile Bai | ... | Yong Cheng
  • Special Issue
  • - Volume 2019
  • - Article ID 2105607
  • - Review Article

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Giovanna Cenini | Ana Lloret | Roberta Cascella
  • Special Issue
  • - Volume 2019
  • - Article ID 1050476
  • - Research Article

Amyloid Peptide β1-42 Induces Integrin αIIbβ3 Activation, Platelet Adhesion, and Thrombus Formation in a NADPH Oxidase-Dependent Manner

Aisha Alsheikh Abubaker | Dina Vara | ... | Giordano Pula
  • Special Issue
  • - Volume 2019
  • - Article ID 4248529
  • - Research Article

Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway

Chen-chen Cai | Jiang-hu Zhu | ... | Zhen-lang Lin
  • Special Issue
  • - Volume 2018
  • - Article ID 1427412
  • - Research Article

Effects of Low-Frequency Electromagnetic Field on Oxidative Stress in Selected Structures of the Central Nervous System

Jan Budziosz | Agata Stanek | ... | Karolina Sieroń
Oxidative Medicine and Cellular Longevity
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