Oxidative Medicine and Cellular Longevity

DNA Damage: Health and Longevity


Publishing date
01 Aug 2018
Status
Published
Submission deadline
30 Mar 2018

1Universidade Federal de Santa Catarina, Florianópolis, Brazil

2Clemente Estable Biological Research Institute, Montevideo, Uruguay

3Universidade Luterana do Brasil, Canoas, Brazil


DNA Damage: Health and Longevity

Description

Damage in both mitochondrial and nuclear DNA can be generated by both endogenous and environmental factors and is involved in the ageing process. Oxidative stress leads to damage of important biomolecules and cells, with potential impact on the whole organism. Most reactive oxygen species (ROS) are generated in cells by the mitochondrial respiratory chain. Furthermore, ageing caused by the accumulation of molecular damage in DNA, proteins, and lipids is also characterized by an increase in intracellular oxidative stress due to the progressive decrease of the intracellular ROS scavenging. Oxidative stress has long been known to be involved in the pathophysiology of many human diseases including, but not restricted to, cancer. Oxidative stress-induced inflammation is a major contributor to several disease conditions, for example, sepsis, carcinogenesis, diabetic complications, and allergic asthma. Inflammatory cytokines can induce DNA damage and inhibit DNA repair, and persistent oxidative/nitrosative stress and excess lipid peroxidation are induced by inflammatory processes in a self-perpetuating process and cause progressive accumulation of DNA damage in target organs. Oxidative stress-induced epigenetic changes associated with malignant transformation have been reported and are important to be considered in pathophysiology of acute and chronic diseases.

The objective of this special issue is to address the relationship between ageing and genome instability, as well as the mechanisms involved in DNA damage. We encourage submissions related to fundamental cell features such as cell differentiation, DNA repair, epigenetic marking, cell cycle regulation, apoptosis, and biomarkers for monitoring exposed populations and studies about age-related disease.

Potential topics include but are not limited to the following:

  • Oxidative damage
  • Free radicals
  • DNA damage detection techniques
  • Cellular DNA damage response (DDR)
  • Chromosome instability syndromes
  • Telomere shortening
  • Epigenetic modifications
  • The role of microRNAs
  • Antioxidants and DNA protectors
  • DNA damage in human disease

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9701647
  • - Editorial

DNA Damage: Health and Longevity

Sharbel Weidner Maluf | Wilner Martínez-López | Juliana da Silva
  • Special Issue
  • - Volume 2018
  • - Article ID 7804135
  • - Research Article

Biotoxicological Analyses of Trimeroside from Baccharis trimera Using a Battery of In Vitro Test Systems

Marcela Silva dos Santos | Juliana da Silva | ... | Alexandre de Barros Falcão Ferraz
  • Special Issue
  • - Volume 2018
  • - Article ID 3862070
  • - Research Article

ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells

Takahito Moriwaki | Akira Yamasaki | Qiu-Mei Zhang-Akiyama
  • Special Issue
  • - Volume 2018
  • - Article ID 2846819
  • - Research Article

Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments

Márcia Fernanda Correia Jardim Paz | André Luiz Pinho Sobral | ... | Juliana da Silva
  • Special Issue
  • - Volume 2018
  • - Article ID 7017423
  • - Research Article

Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability

Vivian F. Silva Kahl | Varinderpal Dhillon | ... | Juliana da Silva
  • Special Issue
  • - Volume 2018
  • - Article ID 2984730
  • - Review Article

Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population

Yeo Jin Kim | Hyun Soo Kim | Young Rok Seo
  • Special Issue
  • - Volume 2018
  • - Article ID 3570526
  • - Research Article

DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress

Rodrigo S. Fortunato | Luciana R. Gomes | ... | Carlos Frederico Martins Menck
  • Special Issue
  • - Volume 2018
  • - Article ID 6918797
  • - Research Article

Hypermethylation of TRIM59 and KLF14 Influences Cell Death Signaling in Familial Alzheimer’s Disease

Michalina Wezyk | Magdalena Spólnicka | ... | Cezary Żekanowski
  • Special Issue
  • - Volume 2018
  • - Article ID 7820890
  • - Research Article

Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries

Carlos F. Araujo-Lima | Larissa S. A. Christoni | ... | Israel Felzenszwalb
  • Special Issue
  • - Volume 2018
  • - Article ID 5413056
  • - Research Article

Effect of Heat Stress on Sperm DNA: Protamine Assessment in Ram Spermatozoa and Testicle

Thais Rose dos Santos Hamilton | Adriano Felipe Perez Siqueira | ... | Mayra Elena Ortiz D. Ávila Assumpção
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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