Oxidative Medicine and Cellular Longevity

The Interplay of Oxidative Stress and Inflammation: Mechanistic Insights and Therapeutic Potential of Antioxidants


Publishing date
01 Jun 2020
Status
Closed
Submission deadline
24 Jan 2020

1Beni-Suef University, Beni Suef, Egypt

2Manchester Metropolitan University, Manchester, UK

3PMAS-Arid Agriculture University, Rawalpindi, Pakistan

This issue is now closed for submissions.
More articles will be published in the near future.

The Interplay of Oxidative Stress and Inflammation: Mechanistic Insights and Therapeutic Potential of Antioxidants

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress is caused by the overproduction of Reactive Oxygen Species (ROS) and diminished cellular antioxidant defenses. Under physiological conditions, ROS are involved in processes, including cellular homeostasis, modulation of cellular metabolism, signaling and redox state, and being used by the immune system to inactivate viruses and inhibit bacterial growth. However, excess ROS production can damage lipids, DNA, and proteins which can lead to cell death. ROS-induced damage underpins various oxidative stress-related human diseases and aging. In addition, the cellular antioxidant defenses may decrease during aging which results in age-related increase of ROS and oxidative stress. Excess ROS can also activate the proinflammatory signaling pathways and the release of multiple inflammatory mediators, such as cytokines, chemokines, eicosanoids, and others. Therefore, oxidative stress is implicated in the pathogenesis, development, and progression of a sustained inflammatory state. Furthermore, excess ROS and inflammation work together to trigger and orchestrate necrotic and apoptotic cell death, where mitochondrial dysfunction, caspase activation, and Bcl-2 family proteins are involved in ROS-mediated apoptosis. In addition, several protein kinases and signaling pathways (including mitogen-activated protein kinases, nuclear factor-kappaB, protein kinase C, and others) modulate apoptosis depending on the cellular context.

Oxidative stress and inflammation are increasingly recognized as having key roles in the pathogenesis of various diseases, including diabetes, obesity, cancer, neurodegeneration, metabolic syndrome, cardiovascular disease, liver disease, and others. Therefore, understanding the molecular mechanisms underlying the mutual relationship between oxidative stress and inflammation can lead to the discovery of novel strategies to prevent and/or treat various diseases. Although the cells are equipped with numerous nonenzymatic molecules and enzymatic scavengers of ROS, these defenses are not always adequate to attenuate the excess ROS production. Therefore, agents that can boost antioxidant defense mechanisms and prevent increased ROS generation can represent an effective treatment for oxidative stress/inflammation-related diseases.

We invite investigators to contribute original research and review articles that will help to elucidate the role of oxidative stress/inflammation interplay in the pathophysiology and progression of diseases. We encourage the submission of in vitro, in vivo, and clinical studies describing the role of oxidative stress and inflammation in different diseases and the modulatory role of antioxidant and anti-inflammatory agents.

Potential topics include but are not limited to the following:

  • Role of oxidative stress and inflammation in different human diseases
  • Strategies to prevent/treat oxidative stress/inflammation-related diseases
  • Role of ROS and inflammatory mediators in cell death
  • Molecular mechanisms of oxidative stress in different diseases
  • New findings on potential antioxidant/anti-inflammatory agents
  • Modulators of the redox-sensitive transcription factors
  • Biomarkers of oxidative stress and inflammation in metabolic diseases and drug-induced injury

Articles

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Retracted: Hydrostatin-SN10 Ameliorates Pancreatitis-Induced Lung Injury by Affecting IL-6-Induced JAK2/STAT3-Associated Inflammation and Oxidative Stress

Oxidative Medicine and Cellular Longevity
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PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease

Apor Veres-Székely | Mária Bernáth | ... | Ádám Vannay
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  • - Article ID 5291852
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Inhibition of JNK Alleviates Chronic Hypoperfusion-Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2/HO-1 and NF-κB Signaling

Muhammad Sohail Khan | Amjad Khan | ... | Myeong Ok Kim
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  • - Article ID 7956274
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Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1β Pathway

Junteng Zhou | Geer Tian | ... | Xiaojing Liu
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  • - Article ID 6384803
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FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway

Bing Zhou | Yun Qiu | ... | Guo-Qing Zhu
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  • - Article ID 1954398
  • - Review Article

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Arthur José Pontes Oliveira de Almeida | Mathania Silva de Almeida Rezende | ... | Isac Almeida de Medeiros
  • Special Issue
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  • - Article ID 1298691
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Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice

A Young Min | Jae-Myung Yoo | ... | Mee Ree Kim
  • Special Issue
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  • - Article ID 1675957
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Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Emad H. M. Hassanein | Ahmed M. Sayed | ... | Ayman M. Mahmoud
  • Special Issue
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  • - Article ID 2972968
  • - Review Article

Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges

Ana Paula Vargas Visentin | Rafael Colombo | ... | Mirian Salvador
  • Special Issue
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  • - Article ID 2394704
  • - Research Article

Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties

Qini Zhao | Liquan Yin | ... | Hong Ji
Oxidative Medicine and Cellular Longevity
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CiteScore7.300
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