Oxidative Medicine and Cellular Longevity

Oxidative stress in end-stage renal disease: pathophysiology and potential interventions


Publishing date
01 Jan 2021
Status
Closed
Submission deadline
04 Sep 2020

1Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

2Associate Professor of Nephrology, Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

3Assistant Professor of Nephrology, Department of Nephrology, School of Health Sciences, University of Ioannina, Ioannina, Greece

4Professor of Nephrology, Glasgow Renal and Transplant Unit, University of Glasgow, Glasgow, Scotland, UK

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative stress in end-stage renal disease: pathophysiology and potential interventions

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Chronic kidney disease is a worldwide public health problem with growing epidemic effects. As the disease progresses to the end-stage renal disease, the risks for cardiovascular morbidity and mortality are significantly increased. During recent years, oxidative stress has emerged as a novel, independent risk factor for several adverse events in these patients, including mortality. Oxidative stress is present even in the early stages of uremia, which is gradually increased with renal function deterioration and is further exacerbated by renal replacement therapies. Moreover, it is partially inversed in kidney transplant recipients. In end-stage renal disease, oxidative stress is severely interrelated with conditions such as inflammation, anemia and malnutrition which predispose to premature death and accelerated atherosclerosis. Therefore, understanding the cellular and molecular mechanisms underlying the pathogenesis of oxidative stress in uremic patients may lead to the discovery of strategies to prevent or even treat various oxidative stress-mediated complications.

Over the past few decades, there has been a growing body of evidence highlighting the pivotal role of oxidative stress in end-stage renal disease patients. However, the etiology of this heavy oxidative burden seen in these patients and the possible beneficial effects of antioxidant agents have not been thoroughly studied.

In this Special Issue, we invite investigators to contribute original research and review articles that will help elucidate the effect of oxidative stress in end-stage renal disease patients (including kidney transplant recipients, hemodialysis and peritoneal dialysis). We encourage the submission of in vitro, in vivo, clinical studies and reviews describing the interplay between oxidative stress and inflammation, the pathophysiological mechanisms underlying these associations and the modulatory roles of antioxidant and anti-inflammatory agents.

Potential topics include but are not limited to the following:

  • Oxidative stress in kidney transplant recipients
  • Oxidative stress in hemodialysis and peritoneal dialysis: comparison between dialysis modalities
  • Strategies to prevent/treat oxidative stress (role of antioxidants such as exogenous supplementation with Vitamins C+E, N-acetylcysteine, use of Vitamin E coated membranes, use of on-line hemodiafiltration with ultrapure dialysate, use of alternative methods and types of intravenous iron infusion)
  • Effect of dialysis membranes on the clinical management of hemodialysis patients
  • Molecular mechanisms of oxidative stress: impact of dialysis modalities and kidney transplantation and effect of intravenous or orally administered medication on formation of pro-inflammatory molecules and reactive oxygen species
  • Oxidative stress as a risk factor for cardiovascular disease and mortality

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 6677012
  • - Research Article

Association between PCSK9 Levels and Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction in a Population of Nondialysis Chronic Kidney Disease Patients

Evangelia Dounousi | Constantinos Tellis | ... | Alexandros D. Tselepis
  • Special Issue
  • - Volume 2021
  • - Article ID 8817502
  • - Research Article

Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease

Stefanos Roumeliotis | Athanasios Roumeliotis | ... | Vassilios Liakopoulos
  • Special Issue
  • - Volume 2021
  • - Article ID 6691226
  • - Research Article

General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease

Tingting Lv | Yao Lu | ... | Qiang Wan
  • Special Issue
  • - Volume 2020
  • - Article ID 2975256
  • - Review Article

Plasma Protein Carbonyls as Biomarkers of Oxidative Stress in Chronic Kidney Disease, Dialysis, and Transplantation

Graziano Colombo | Francesco Reggiani | ... | Isabella Dalle-Donne
  • Special Issue
  • - Volume 2020
  • - Article ID 8209727
  • - Research Article

Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity

Andrej Veljković | Jovan Hadži- Đokić | ... | Gordana Kocić
  • Special Issue
  • - Volume 2020
  • - Article ID 4074832
  • - Research Article

Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling

Wei Huang | Yi Man | ... | Yong Xu
  • Special Issue
  • - Volume 2020
  • - Article ID 2978340
  • - Research Article

Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model

Akinjide Moses Akinnuga | Angezwa Siboto | ... | Andile Khathi
  • Special Issue
  • - Volume 2020
  • - Article ID 9820168
  • - Research Article

Renoprotective Effects of a New Free Radical Scavenger, XH-003, against Cisplatin-Induced Nephrotoxicity

Ya-Hong Liu | Kui Li | Hong-Qi Tian
Oxidative Medicine and Cellular Longevity
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