Oxidative Medicine and Cellular Longevity

Oxidative Stress to Promote Cell Death or Survival


Status
Published

1University of Urbino Carlo Bo, Urbino, Italy

2University of Verona, Verona, Italy

3Italian National Institute of Health, Rome, Italy


Oxidative Stress to Promote Cell Death or Survival

Description

Reactive oxygen species (ROS), either endogenously generated or derived from the environment, are usually removed by the physiological antioxidant mechanisms of the cell; whenever ROS production exceeds the scavenging capability of the biological system, cells undergo oxidative stress, and their molecular component—proteins, lipids, nucleic acids—may be seriously damaged.

The cellular effects of oxidative stress depend on the response of the different organelles and the extent of the induced damages. In the presence of severe injury, cell death may occur by catastrophic events (i.e., by necrosis) or by regulated forms (such as apoptosis, parthanatos, and anoikis). Conversely, in the presence of a mild oxidative stress, the cells may activate metabolic responses which promote repair and survival.

A variety of physical or chemical stimuli may be used under controlled conditions to induce oxidative stress, in the attempt to either selectively cause cell damage and death or to activate cell metabolism. The scope of this special issue is to elucidate the potential of oxidative stress as a powerful versatile tool for multiple biomedical applications. Scientists working on a wide variety of topics, such as development, aging, cancer, cardiovascular, and neuromuscular and neurodegenerative diseases in cellular and animal model systems as well as in humans are encouraged to submit a paper.

Potential topics include, but are not limited to:

  • Apoptosis
  • Anoikis
  • Necrosis
  • Parthanatos
  • Autophagy
  • Organelle damage and repair
  • Cell nuclear activities

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 2054650
  • - Editorial

Oxidative Stress to Promote Cell Death or Survival

Michela Battistelli | Manuela Malatesta | Stefania Meschini
  • Special Issue
  • - Volume 2016
  • - Article ID 8213071
  • - Research Article

Sperm Oxidative Stress Is Detrimental to Embryo Development: A Dose-Dependent Study Model and a New and More Sensitive Oxidative Status Evaluation

Letícia S. de Castro | Patrícia M. de Assis | ... | Mayra E. O. A. Assumpção
  • Special Issue
  • - Volume 2016
  • - Article ID 4512309
  • - Research Article

Acetaldehyde Induces Cytotoxicity of SH-SY5Y Cells via Inhibition of Akt Activation and Induction of Oxidative Stress

Tingting Yan | Yan Zhao | Xia Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 8923860
  • - Research Article

Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells

Tingting Dou | Mengling Yan | ... | Zhijun Zhou
  • Special Issue
  • - Volume 2016
  • - Article ID 5910695
  • - Research Article

Redox Stimulation of Human THP-1 Monocytes in Response to Cold Physical Plasma

Sander Bekeschus | Anke Schmidt | ... | Kristian Wende
  • Special Issue
  • - Volume 2016
  • - Article ID 9636937
  • - Research Article

Intermittent Hypoxia Affects the Spontaneous Differentiation In Vitro of Human Neutrophils into Long-Lived Giant Phagocytes

Larissa Dyugovskaya | Slava Berger | ... | Lena Lavie
  • Special Issue
  • - Volume 2015
  • - Article ID 671839
  • - Research Article

hCLOCK Causes Rho-Kinase-Mediated Endothelial Dysfunction and NF-κB-Mediated Inflammatory Responses

Xiao Tang | Daqiao Guo | ... | Longhua Fan
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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