Redox Perturbations in Exercise and Inflammation
1University of Thessaly, Trikala, Greece
2University of Wolverhampton, Walsall, UK
Redox Perturbations in Exercise and Inflammation
Description
Exercise is a stimulus with redox-altering properties due to its ability to induce alterations in blood and tissue redox status in vivo and in vitro. Acute exercise is an excellent experimental model to induce oxidative stress and an inflammatory response, whereas chronic exercise is accompanied by useful adaptations both at the systemic and molecular level (i.e. it reverses detrimental redox perturbations, reduces inflammation, and improves antioxidant capacity in vivo).
Oxidative stress is a biological phenomenon that was originally defined more than 3 decades ago and re-defined recently. Similarly, the idea that free radicals, and reactive species in general, exert exclusively detrimental action on biomolecules has been rejected. Instead, a perception shift has emerged following insightful experimental approaches that have revealed the participation of these biologically interesting chemical compounds in fundamental cellular processes, implying that, in specific concentration ranges, they are totally necessary to preserve cellular function. On the other hand, chronic oxidative stress and low-grade systemic inflammation are considered significant causative factors for several chronic diseases and age-related conditions. Therefore, chronic exercise is considered a prospective non-pharmaceutical strategy aimed at alleviating these two factors.
This Special Issue invites researchers to contribute original research or review articles that approach the modern trends in redox biology under the frame of exercise and oxidative stress/inflammation.
Potential topics include but are not limited to the following:
- Human and animal studies examining how exercise modifies redox status and affects redox perturbations
- Studies investigating the potential of antioxidant supplementation strategies to alleviate exercise-induced inflammation
- Evaluation of the (anti)oxidant and (anti)inflammatory activity of compounds using in vitro tests
- Oxidative stress and inflammation in health and disease
- Mechanisms of inflammatory response in vitro and in vivo
- Oxidative stress and reductive stress in health and disease
- Articles dealing with the modern theoretical approaches on the perturbations of redox equilibrium
- Epistemological aspects of redox biology and the biochemistry of exercise