Oxidative Medicine and Cellular Longevity

Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress


Publishing date
01 Sep 2018
Status
Published
Submission deadline
27 Apr 2018

Lead Editor

1Albert Einstein College of Medicine, Bronx, USA

2University of Potsdam, Nuthetal, Germany

3Vanderbilt University Medical Center, Nashville, USA

4Federal University of Pampa, Uruguaiana, Brazil


Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress

Description

With the thriving of modern industry, people are exposed to various metals in the environment. Many metals (trace metals such as copper, iron, manganese, and zinc) are essential for cellular activities; however, excessive exposure to such metals can lead to toxicity and eventually cell death. Increasing environmental exposure and fortification of food sources with various metallic compounds are causing growing concerns that imbalances in metal content may contribute to the etiology of various human diseases, including cancer, hepatic diseases, and especially neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Redox-active metals, such as iron, copper, and other transition metals, can undergo redox cycling reactions resulting in the production of reactive oxygen/nitrogen species (RONS) and mitochondrial dysfunction. Disruption of intracellular redox state and energy production leads to oxidative stress, protein unfolding/misfolding, DNA damage, endoplasmic reticulum (ER) stress, autophagosome dysfunction, and apoptosis, cellular responses observed in the development of diseases, such as cancer, diabetes, and neurodegenerative diseases.

Despite recent advances in biomedical sciences, the mechanisms underlying the toxicity of metals are in many cases not fully established. Here, we invite researchers to submit original research articles and reviews relevant to this special issue.

Potential topics include but are not limited to the following:

  • Potential topics include but are not limited to the following:
  • Metal-induced oxidative stress
  • DNA damage in metal toxicity
  • Role of protein folding and ER stress in metal toxicity
  • Inflammation and metal toxicity
  • Metal-induced apoptosis, necrosis, and necroptosis
  • Metal exposure and cellular longevity
  • Natural products, synthetic compounds, endogenous molecules, and genetic strategies to counteract metal toxicity

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7612172
  • - Editorial

Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress

Pan Chen | Julia Bornhorst | ... | Daiana S. Avila
  • Special Issue
  • - Volume 2018
  • - Article ID 4285694
  • - Research Article

Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity

Herbert R. Marini | Domenico Puzzolo | ... | Letteria Minutoli
  • Special Issue
  • - Volume 2018
  • - Article ID 7878050
  • - Research Article

Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death

Walessa Alana Bragança Aragão | Francisco Bruno Teixeira | ... | Rafael Rodrigues Lima
  • Special Issue
  • - Volume 2018
  • - Article ID 7580707
  • - Review Article

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

Longman Li | Xiaobo Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 8949450
  • - Research Article

Ex Vivo Cardiotoxicity of Antineoplastic Casiopeinas Is Mediated through Energetic Dysfunction and Triggered Mitochondrial-Dependent Apoptosis

Christian Silva-Platas | César A. Villegas | ... | Gerardo García-Rivas
  • Special Issue
  • - Volume 2018
  • - Article ID 2850341
  • - Review Article

Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology

Romina María Uranga | Gabriela Alejandra Salvador
  • Special Issue
  • - Volume 2017
  • - Article ID 7028583
  • - Review Article

Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines

Roberto Zefferino | Claudia Piccoli | ... | Nazzareno Capitanio
  • Special Issue
  • - Volume 2017
  • - Article ID 8763793
  • - Research Article

The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans

Michał Dobrakowski | Marta Boroń | ... | Sławomir Kasperczyk
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.900
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Impact Factor6.543
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