Oxidative Medicine and Cellular Longevity

Mitochondrial Quality Control Mechanisms as Molecular Targets in Cardiovascular Disorders


Publishing date
01 Apr 2021
Status
Closed
Submission deadline
04 Dec 2020

Lead Editor
Guest Editors

1Chinese PLA General Hospital, Beijing, China

2University of Minnesota, Duluth, USA

3Hebei University, Hebei, China

This issue is now closed for submissions.
More articles will be published in the near future.

Mitochondrial Quality Control Mechanisms as Molecular Targets in Cardiovascular Disorders

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Mitochondrial quality control (MQC) is an adaptive response that adjusts the morphology and function of mitochondria during cardiovascular disorders. After exposure to stress, cardiomyocytes employ antioxidative factors to neutralize mitochondrial ROS, reduce oxidative stress damage, and ensure mitochondrial homeostasis. Concurrently, mitochondrial fission is activated so that damaged mitochondrial fractions can be removed from the mitochondrial network, with the cooperation of mitophagy. In contrast, healthy, long mitochondria can integrate with several small mitochondrial fragments to enhance the resistance of the entire mitochondrial population to stress. When these adaptive responses fail, programmed cell death by apoptosis or necroptosis is activated, and damaged mitochondria become the inducers of cell death, enabling the sequestration of incurable and dysfunctional cardiomyocytes.

During this process, mitochondrial fission and mitophagy serve as a double-edged sword in the damaged heart: on the one hand, they exert prosurvival mechanisms by isolating damaged mitochondria, and on the other hand, if fission and mitophagy persist beyond a certain threshold, they may lead to cellular demise. Therefore, selective, effective, moderate, and differential activation of mitophagy and mitigation of fission are essential for MQC and could synergistically sustain cardiac function. Necroptosis and apoptosis, although activated by various stimuli, are functionally governed solely by mitochondria. As the final steps of MQC to maintain tissue homeostasis, necroptosis and apoptosis communicate with each other and offer new targets for therapeutic approaches. Therefore, defects in MQC may determine the fate of cardiomyocytes.

The aim of this Special Issue is to collate original research and review articles that discuss the regulatory mechanisms and pathological effects of MQC in cardiovascular diseases, highlighting potential targets for the clinical management of acute and chronic myocardial injuries.

Potential topics include but are not limited to the following:

  • New insights into the mechanisms underlying dysregulated mitochondrial quality control in the pathogenesis of myocardial and microvascular injuries
  • The roles of oxidative stress, mitochondrial fission, mitochondrial fusion, mitochondrial biogenesis, mitophagy, mitochondria-induced death, and mitochondrial unfolded protein response in cardiovascular disorders
  • Mitochondria-targeted approaches (such as melatonin or mitochondria-derived peptides) to attenuate the vulnerability of cardiomyocytes and endothelial cells to stressful conditions including oxidative stress, hypoxia, inflammation, ischemia-reperfusion injury, hyperglycemia, and lipotoxicity
  • Clinically relevant information on the effects of therapies for myocardium and microvessels with a focus on mitochondria
  • Novel approaches to modulate mitochondrial integrity and thus improve cardiovascular function during stressful conditions

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 8877296
  • - Research Article

Effects of Xuefu Zhuyu Granules on Patients with Stable Coronary Heart Disease: A Double-Blind, Randomized, and Placebo-Controlled Study

Yuzhen Li | Tianqi Tao | ... | Xiuhua Liu
  • Special Issue
  • - Volume 2021
  • - Article ID 6663948
  • - Research Article

Epicardial Adipose Tissue Volume Is Associated with High Risk Plaque Profiles in Suspect CAD Patients

Dongkai Shan | Guanhua Dou | ... | Yang Li
  • Special Issue
  • - Volume 2021
  • - Article ID 6699054
  • - Research Article

Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene

Shengqi Huo | Wei Shi | ... | Li Lin
  • Special Issue
  • - Volume 2021
  • - Article ID 6685468
  • - Review Article

Involvement of Mitochondrial Dynamics and Mitophagy in Sevoflurane-Induced Cell Toxicity

Ming Li | Jiguang Guo | ... | Yuzhen Li
  • Special Issue
  • - Volume 2021
  • - Article ID 6643871
  • - Research Article

Modulation of Mitochondrial Quality Control Processes by BGP-15 in Oxidative Stress Scenarios: From Cell Culture to Heart Failure

Orsolya Horvath | Katalin Ordog | ... | Laszlo Deres
  • Special Issue
  • - Volume 2021
  • - Article ID 6659240
  • - Research Article

Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control

Xing Chang | Tian Zhang | ... | XiuTeng Zhou
  • Special Issue
  • - Volume 2021
  • - Article ID 6669075
  • - Review Article

Novel Insights into the Molecular Features and Regulatory Mechanisms of Mitochondrial Dynamic Disorder in the Pathogenesis of Cardiovascular Disease

Ying Tan | Fengfan Xia | ... | Zhongqing Chen
  • Special Issue
  • - Volume 2021
  • - Article ID 6635836
  • - Review Article

The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

Jinlin Liu | Li Zhong | Rui Guo
  • Special Issue
  • - Volume 2021
  • - Article ID 6621232
  • - Research Article

S-Nitroso-L-Cysteine Ameliorated Pulmonary Hypertension in the MCT-Induced Rats through Anti-ROS and Anti-Inflammatory Pathways

Moran Wang | Pengcheng Luo | ... | Sheng Li
  • Special Issue
  • - Volume 2021
  • - Article ID 6620677
  • - Review Article

Natural Antioxidants Improve the Vulnerability of Cardiomyocytes and Vascular Endothelial Cells under Stress Conditions: A Focus on Mitochondrial Quality Control

Xing Chang | Zhenyu Zhao | ... | Ming Zhang
Oxidative Medicine and Cellular Longevity
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