Oxidative Medicine and Cellular Longevity

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics


Publishing date
01 Nov 2021
Status
Closed
Submission deadline
18 Jun 2021

Lead Editor

1Third Hospital of Hebei Medical University, Shijiazhuang, China

2University of Sydney, Sydney, Australia

3University of New South Wales, Sydney, Australia

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Intervertebral disc (IVD) degeneration, an important cause of discogenic lower back pain (LBP), has traditionally been thought to be an age-related process of the disc tissue caused by decreased proteoglycan content, eventually leading to decreased intervertebral height, endplate sclerosis and osteophyte formation. IVD degeneration can cause a variety of spinal diseases including lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy. Over the past decades, IVD degeneration-related diseases have been causing an enormous socio-economic burden and leading to low quality of life.

The process of IVD degeneration is complicated. Although the mechanism of IVD degeneration is not fully understood, altered mechanical loading, degradation of the extracellular matrix (ECM), increased secretion of inflammatory factors, excessive senescence, and aberrant apoptosis of IVD cells have proved to play important roles in the progression of IVD degeneration. Previous studies in humans and experimental animal models have well documented that oxidative stress and damage can result in excessive apoptosis and autophagy of IVD cells and further lead to IVD degeneration. However, the specific signalling pathways underlying the pathogenesis still remain elusive, making it very difficult to find potential therapeutics targeting that unclear mechanism.

This Special Issue will focus on the specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing, as well as potential therapeutic molecules to attenuate the progression of IVD degeneration. In particular, the effect of steroids (e.g., estrogen) on delaying IVD degeneration and ageing, in terms of both in vivo and in vitro investigations. Contributions with original research are extremely welcome if that would provide new insights for understanding the pathophysiological mechanism of oxidative damage-induced IVD degeneration and/or novel discovery of its diagnostics and therapeutics. Review articles that help better understand the existing knowledge regarding the role of oxidative stress and related therapeutics are also encouraged.

Potential topics include but are not limited to the following:

  • Oxidative stress in IVD degeneration and aging related diseases, including LBP, lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy
  • Specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing
  • Potential therapeutic molecules to attenuate the progression of IVD degeneration
  • Novel or potential diagnostics and prognosis for IVD degeneration and ageing related diseases
  • Original research on potential medicinal plants are also welcome if the mechanism or molecular targets are also elucidated in treating IVD degeneration-related diseases
  • Bioinformatical analysis of the underlying mechanisms related to oxidative stress-induced IVD degenerative diseases, including but not limited to differential gene expression, functional and pathway enrichment analyses, and module analyses for protein-protein interaction (PPI) network
  • Bioengineering therapeutics for oxidative stress-induced IVD degenerative diseases
  • Meta-analysis of randomized controlled trials or primary clinical data used to evaluate the efficacy, or otherwise, of novel or potential therapeutics for IVD degeneration-related diseases

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 6681815
  • - Research Article

Reactive Oxygen Species Mediate Low Back Pain by Upregulating Substance P in Intervertebral Disc Degeneration

Jiancheng Zheng | Jian Zhang | ... | Jitian Li
  • Special Issue
  • - Volume 2021
  • - Article ID 5558687
  • - Research Article

Ulinastatin Ameliorates IL-1β-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2/NF-κB Pathway

Xi Luo | Le Huan | ... | Jiangang Shi
  • Special Issue
  • - Volume 2021
  • - Article ID 6640751
  • - Research Article

Follistatin-Like 1 Attenuation Suppresses Intervertebral Disc Degeneration in Mice through Interacting with TNF-α and Smad Signaling Pathway

Shaoyi Wang | Jianlu Wei | ... | Lei Cheng
  • Special Issue
  • - Volume 2021
  • - Article ID 6492879
  • - Research Article

The Role of Unfolded Protein Response in Human Intervertebral Disc Degeneration: Perk and IRE1-α as Two Potential Therapeutic Targets

Tianyong Wen | Peng Xue | ... | Dike Ruan
  • Special Issue
  • - Volume 2021
  • - Article ID 6629037
  • - Review Article

Research Progress on the Mechanism of Lumbarmultifidus Injury and Degeneration

Xianzheng Wang | Rui Jia | ... | Wei Zhang
  • Special Issue
  • - Volume 2021
  • - Article ID 6672978
  • - Research Article

Salvianolic Acid B Protects Intervertebral Discs from Oxidative Stress-Induced Degeneration via Activation of the JAK2/STAT3 Signaling Pathway

Shouqian Dai | Ting Liang | ... | Huilin Yang
  • Special Issue
  • - Volume 2021
  • - Article ID 6670497
  • - Research Article

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo

Saideng Lu | Yu Song | ... | Cao Yang
  • Special Issue
  • - Volume 2021
  • - Article ID 8884922
  • - Research Article

Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration

Bingjin Wang | Wencan Ke | ... | Cao Yang
  • Special Issue
  • - Volume 2021
  • - Article ID 6645005
  • - Research Article

Long Noncoding RNA ANPODRT Overexpression Protects Nucleus Pulposus Cells from Oxidative Stress and Apoptosis by Activating Keap1-Nrf2 Signaling

Liang Kang | Yueyang Tian | ... | Yuan Xue
  • Special Issue
  • - Volume 2021
  • - Article ID 6684147
  • - Research Article

Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway

Dawei Song | Jun Ge | ... | Jun Zou
Oxidative Medicine and Cellular Longevity
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