Oxidative Medicine and Cellular Longevity

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics


Publishing date
01 Nov 2021
Status
Closed
Submission deadline
18 Jun 2021

Lead Editor

1Third Hospital of Hebei Medical University, Shijiazhuang, China

2University of Sydney, Sydney, Australia

3University of New South Wales, Sydney, Australia

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Intervertebral disc (IVD) degeneration, an important cause of discogenic lower back pain (LBP), has traditionally been thought to be an age-related process of the disc tissue caused by decreased proteoglycan content, eventually leading to decreased intervertebral height, endplate sclerosis and osteophyte formation. IVD degeneration can cause a variety of spinal diseases including lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy. Over the past decades, IVD degeneration-related diseases have been causing an enormous socio-economic burden and leading to low quality of life.

The process of IVD degeneration is complicated. Although the mechanism of IVD degeneration is not fully understood, altered mechanical loading, degradation of the extracellular matrix (ECM), increased secretion of inflammatory factors, excessive senescence, and aberrant apoptosis of IVD cells have proved to play important roles in the progression of IVD degeneration. Previous studies in humans and experimental animal models have well documented that oxidative stress and damage can result in excessive apoptosis and autophagy of IVD cells and further lead to IVD degeneration. However, the specific signalling pathways underlying the pathogenesis still remain elusive, making it very difficult to find potential therapeutics targeting that unclear mechanism.

This Special Issue will focus on the specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing, as well as potential therapeutic molecules to attenuate the progression of IVD degeneration. In particular, the effect of steroids (e.g., estrogen) on delaying IVD degeneration and ageing, in terms of both in vivo and in vitro investigations. Contributions with original research are extremely welcome if that would provide new insights for understanding the pathophysiological mechanism of oxidative damage-induced IVD degeneration and/or novel discovery of its diagnostics and therapeutics. Review articles that help better understand the existing knowledge regarding the role of oxidative stress and related therapeutics are also encouraged.

Potential topics include but are not limited to the following:

  • Oxidative stress in IVD degeneration and aging related diseases, including LBP, lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy
  • Specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing
  • Potential therapeutic molecules to attenuate the progression of IVD degeneration
  • Novel or potential diagnostics and prognosis for IVD degeneration and ageing related diseases
  • Original research on potential medicinal plants are also welcome if the mechanism or molecular targets are also elucidated in treating IVD degeneration-related diseases
  • Bioinformatical analysis of the underlying mechanisms related to oxidative stress-induced IVD degenerative diseases, including but not limited to differential gene expression, functional and pathway enrichment analyses, and module analyses for protein-protein interaction (PPI) network
  • Bioengineering therapeutics for oxidative stress-induced IVD degenerative diseases
  • Meta-analysis of randomized controlled trials or primary clinical data used to evaluate the efficacy, or otherwise, of novel or potential therapeutics for IVD degeneration-related diseases

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 6660429
  • - Research Article

Danshen Attenuates Intervertebral Disc Degeneration via Antioxidation in SD Rats

Rongqing Qin | Shouqian Dai | ... | Chuanliang Hu
  • Special Issue
  • - Volume 2020
  • - Article ID 6685043
  • - Research Article

Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells

Qian Xiang | Zhangrong Cheng | ... | Yukun Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 8189706
  • - Research Article

Overexpression of LMP-1 Decreases Apoptosis in Human Nucleus Pulposus Cells via Suppressing the NF-κB Signaling Pathway

Yuan Liu | Wei Zhou | ... | Guan-Cheng Guo
  • Special Issue
  • - Volume 2020
  • - Article ID 6697577
  • - Research Article

Exosomes Derived from Human Urine-Derived Stem Cells Inhibit Intervertebral Disc Degeneration by Ameliorating Endoplasmic Reticulum Stress

HongFei Xiang | WeiLiang Su | ... | BoHua Chen
  • Special Issue
  • - Volume 2020
  • - Article ID 8880320
  • - Review Article

Mitochondrial Dysfunction in Intervertebral Disc Degeneration: From Pathogenesis to Therapeutic Target

Danni Li | Fenghua Tao | Lin Jin
  • Special Issue
  • - Volume 2020
  • - Article ID 8893819
  • - Review Article

Effect of Platelet-Rich Plasma on Intervertebral Disc Degeneration In Vivo and In Vitro: A Critical Review

Yvang Chang | Ming Yang | ... | Zhonghai Li
  • Special Issue
  • - Volume 2020
  • - Article ID 9503562
  • - Review Article

Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration

Yuang Zhang | Biao Yang | ... | Qixin Chen
Oxidative Medicine and Cellular Longevity
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Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.900
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Impact Factor6.543
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.