Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species in Cancer Biology and Anticancer Therapy


Publishing date
05 Aug 2016
Status
Published
Submission deadline
18 Mar 2016

1Ludwig Maximilians University Munich, Munich, Germany

2University of Heidelberg, Heidelberg, Germany

3Moscow State University, Moscow, Russia


Reactive Oxygen Species in Cancer Biology and Anticancer Therapy

Description

Our understanding of reactive oxygen species (ROS) has changed in the last few years from ROS as just harmful substances to crucial intra- and extracellular messengers as well as important regulators controlling a wide spectrum of signaling pathways. Nevertheless, there are many uninvestigated points and open questions regarding ROS, especially in pathophysiology.

ROS are a group of highly reactive chemicals containing oxygen. Due to their high reactivity, ROS can damage many intracellular macromolecules, such as nucleic acids, lipids, and proteins. Under normal conditions, the intracellular ROS level is under tight control by various antioxidants. As a result of increased ROS production and/or impaired ROS detoxification, cancer cells have higher oxidative level as compared with normal cells. ROS production in cancer cells may result from increased or aberrant metabolic activity, mitochondrial dysfunction, disturbed cellular signaling, oncogene activity, and interaction with infiltrated immune cells. Therefore a delicately controlled ROS homeostasis is critical for maintaining normal cell functions. Any disruption in the oxidation-antioxidation balance will lead to oxidative stress which is associated with a wide spectrum of human disorders such as chronic inflammation, age-related diseases, and cancers.

The ultimative purpose of the special issue is to publish high-quality research communications as well as review articles in the field of ROS in cancer biology and anticancer therapy. We invite investigators to disseminate their recent results in the topic of the special issue.

Potential topics include, but are not limited to:

  • Features of ROS and their functions with respect to cancer initiation, progression, and metastasis
  • Molecular mechanisms of ROS acting in cancer cell signaling
  • Cancer treatment strategies based on ROS-elevating and/or ROS-depleting approaches
  • Antioxidants and cancer
  • Roles of reactive oxygen species (ROS) in the immune system

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4197815
  • - Editorial

Reactive Oxygen Species in Cancer Biology and Anticancer Therapy

Alexandr V. Bazhin | Pavel P. Philippov | Svetlana Karakhanova
  • Special Issue
  • - Volume 2016
  • - Article ID 2104247
  • - Research Article

Alterations in Red Blood Cell Functionality Induced by an Indole Scaffold Containing a Y-Iminodiketo Moiety: Potential Antiproliferative Conditions

Angela Scala | Silvana Ficarra | ... | Ester Tellone
  • Special Issue
  • - Volume 2016
  • - Article ID 9579868
  • - Review Article

The Janus-Faced Role of Antioxidants in Cancer Cachexia: New Insights on the Established Concepts

Mohamad Assi | Amélie Rébillard
  • Special Issue
  • - Volume 2016
  • - Article ID 5293284
  • - Review Article

Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge

Yu-Chiang Hung | Tai-Long Pan | Wen-Long Hu
  • Special Issue
  • - Volume 2016
  • - Article ID 1580967
  • - Review Article

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

Xinfeng Chen | Mengjia Song | ... | Yi Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 5190314
  • - Research Article

Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide

Wei Li | Lun Zhang | ... | Qingyong Ma
  • Special Issue
  • - Volume 2016
  • - Article ID 1908164
  • - Review Article

Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications

Gabriela Vilema-Enríquez | Aurora Arroyo | ... | Javier Camacho
  • Special Issue
  • - Volume 2016
  • - Article ID 4650489
  • - Research Article

The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation

Maximilian Weniger | Leonard Reinelt | ... | Jan G. D’Haese
  • Special Issue
  • - Volume 2016
  • - Article ID 4782426
  • - Research Article

Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction

Serafina Perrone | Federica Lotti | ... | Giuseppe Buonocore
  • Special Issue
  • - Volume 2016
  • - Article ID 4741694
  • - Research Article

The Combination of α-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit?

Doaa M. Badr | Hafez F. Hafez | ... | Samia A. Shouman
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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