Oxidative Medicine and Cellular Longevity

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics 2021


Publishing date
01 Jul 2022
Status
Closed
Submission deadline
25 Feb 2022

Lead Editor

1Third Hospital of Hebei Medical University, Hebei, China

2Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, P.R. China, Nanjing, China

3Icahn School of Medicine at Mount Sinai, New York, USA

4Department of Orthopedics Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Zhejiang, China

5University of Queensland, St Lucia, Australia

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics 2021

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Intervertebral disc (IVD) degeneration, an important cause of discogenic lower back pain (LBP), has traditionally been thought to be an age-related process of the disc tissue caused by decreased proteoglycan content, eventually leading to decreased intervertebral height, endplate sclerosis and osteophyte formation. IVD degeneration can cause a variety of spinal diseases including lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy. Over the past decades, IVD degeneration-related diseases have been causing an enormous socio-economic burden and leading to low quality of life.

The process of IVD degeneration is complicated. Although the mechanism of IVD degeneration is not fully understood, altered mechanical loading, degradation of the extracellular matrix (ECM), increased secretion of inflammatory factors, excessive senescence, and aberrant apoptosis of IVD cells have proved to play important roles in the progression of IVD degeneration. Previous studies in humans and experimental animal models have well documented that oxidative stress and damage can result in excessive apoptosis and autophagy of IVD cells and further lead to IVD degeneration. However, the specific signalling pathways underlying the pathogenesis still remain elusive, making it very difficult to find potential therapeutics targeting that unclear mechanism.

This issue will mainly focus on four aspects.

1. The specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing.

2. Therapeutic molecules that attenuate the progression of IVD degeneration.

3. Biomaterials for IVD repair and regeneration.

4. Stem/ progenitor cells for IVD repair and regeneration.

Contributions with original research are extremely welcome if that would provide new insights for understanding the pathophysiological mechanism of oxidative damage-induced IVD degeneration and/or novel discovery of its diagnostics and therapeutics. Review articles (including mini-review) that help better understand the existing knowledge regarding the role of oxidative stress and related therapeutics are also welcome. In particular, three-dimensional culture and hypoxic culture of IVD cells are greatly encouraged.

Potential topics include but are not limited to the following:

  • Oxidative stress in IVD degeneration and aging related diseases, including LBP, lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy
  • Specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing
  • Potential therapeutic molecules to attenuate the progression of IVD degeneration
  • Novel or potential diagnostics and prognosis for IVD degeneration- related diseases
  • Original research on potential medicinal plants are also welcome if the mechanism or molecular targets are also elucidated in treating IVD degeneration-related diseases
  • Bioinformatical analysis of the underlying mechanisms related to oxidative stress-induced IVD degenerative diseases, including but not limited to differential gene expression, functional and pathway enrichment analyses, and module analyses for protein-protein interaction (PPI) network
  • Bioengineering therapeutics for oxidative damage-induced IVD degenerative diseases, including biomaterials and stem/progenitor cells
  • IVD degeneration models induced by oxidative damage, including in vivo, ex vivo, and in vitro models
  • Meta-analysis of randomized controlled trials or primary clinical data used to evaluate the efficacy, or otherwise, of novel or potential therapeutics for IVD degeneration-related diseases

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 2912276
  • - Research Article

Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway

Bo Li | Ze-Yu Lu | ... | Xin-Feng Zheng
  • Special Issue
  • - Volume 2022
  • - Article ID 1045999
  • - Research Article

Intervertebral Disc Degeneration and Low Back Pain Depends on Duration and Magnitude of Axial Compression

Jitian Li | Yan Ma | ... | Zhe Chen
  • Special Issue
  • - Volume 2022
  • - Article ID 4235126
  • - Research Article

Silencing ATF3 Might Delay TBHP-Induced Intervertebral Disc Degeneration by Repressing NPC Ferroptosis, Apoptosis, and ECM Degradation

Yongjin Li | Dayu Pan | ... | Baoshan Xu
  • Special Issue
  • - Volume 2022
  • - Article ID 9731800
  • - Research Article

Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration

Huo-Liang Zheng | Wen-Ning Xu | ... | Sheng-Dan Jiang
  • Special Issue
  • - Volume 2022
  • - Article ID 3156245
  • - Research Article

Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System

Zhefeng Chen | Kai Shen | ... | Qiang Zuo
  • Special Issue
  • - Volume 2022
  • - Article ID 7531788
  • - Research Article

Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2

Peng Wang | Shuo Zhang | ... | Zengwu Shao
  • Special Issue
  • - Volume 2022
  • - Article ID 2239770
  • - Research Article

Oxidative Stress in Intervertebral Disc Degeneration: New Insights from Bioinformatic Strategies

Yongzhao Zhao | Qian Xiang | ... | Weishi Li
  • Special Issue
  • - Volume 2022
  • - Article ID 9067611
  • - Research Article

Circadian Rhythm Modulates the Therapeutic Activity of Pulsed Electromagnetic Fields on Intervertebral Disc Degeneration in Rats

Yi Zheng | Yiming Hao | ... | Jinghui Huang
  • Special Issue
  • - Volume 2022
  • - Article ID 1427110
  • - Research Article

1,25(OH)2D3 Mitigates Oxidative Stress-Induced Damage to Nucleus Pulposus-Derived Mesenchymal Stem Cells through PI3K/Akt Pathway

Jun-wu Wang | Lei Zhu | ... | Liang Zhang
  • Special Issue
  • - Volume 2022
  • - Article ID 3613319
  • - Research Article

Tunneling Nanotube-Mediated Mitochondrial Transfer Rescues Nucleus Pulposus Cells from Mitochondrial Dysfunction and Apoptosis

Fan Yang | Yanbin Zhang | ... | Liming Xiong
Oxidative Medicine and Cellular Longevity
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.