Oxidative Medicine and Cellular Longevity

Pathophysiology and Therapeutic Strategies for Perinatal Organ Injury Caused by Disturbed Oxygenation


Publishing date
01 Jul 2022
Status
Closed
Submission deadline
04 Mar 2022

Lead Editor

1University Hospital Essen, Essen, Germany

2Charité-Universitätsmedizin Berlin, Berlin, Germany

3Maastricht University Medical Center, Maastricht, Netherlands

This issue is now closed for submissions.
More articles will be published in the near future.

Pathophysiology and Therapeutic Strategies for Perinatal Organ Injury Caused by Disturbed Oxygenation

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Disturbances in tissue oxygenation have been identified as common sources of perinatal insults, caused by, for example, hypoxia-ischemia, hyperoxia, or placental dysfunction. Common complications associated with these noxious stimuli are intrauterine growth restriction and/or preterm birth, increasing the risk for the development of disorders such as bronchopulmonary dysplasia or cerebral palsy. The underlying molecular and cellular mechanisms involved in the emergence of these diseases include free radical generation, inflammation, and interruption of physiological organ development, leading to detrimental long-term sequelae.

Although our understanding of the pathophysiological hallmarks in most affected organs, like the placenta, lungs, and the brain has increased tremendously, standard care in the perinatal period is still limited. Therefore, there is a great need to improve our understanding of the underlying mechanisms in the development of oxidative stress, inflammatory responses, and their effects on the premature organism. This basic scientific knowledge can then be used to identify new therapeutic targets to increase long-term survival and to improve the quality of life of infants and their families.

This Special Issue aims to collect both original research and review articles covering recent biomedical or clinical findings related to disturbed perinatal oxygenation and new pharmacological or cell-based regenerative approaches as potential therapeutic options to ameliorate otherwise long-lasting deleterious consequences on organ development.

Potential topics include but are not limited to the following:

  • Mechanisms of oxidative stress-related lung and brain injury caused by hyperoxia or hypoxia-ischemia
  • The role of oxidative stress in intrauterine growth restriction (IUGR)/fetal growth restriction and its consequences on brain and lung development
  • Interaction between oxidative stress and inflammatory responses in the development of pulmonary, cardiovascular, metabolic, and neurodegenerative disorders of preterm infants
  • Recent therapeutic advances to ameliorate oxidative stress-related organ injury (pharmacological or cell-based regenerative approaches)
  • Clinical use of antioxidants to treat respiratory instability
  • Interplay between oxidative stress, antioxidative therapy, and inflammatory responses in the development of lung and brain injury
  • Limitations and improvements of oxygen therapy in standard care of preterm neonates

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 3024032
  • - Research Article

Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth-Restricted Foetuses upon Experimental Preeclampsia

Rebekka Vogtmann | Lilo Valerie Burk | ... | Alexandra Gellhaus
  • Special Issue
  • - Volume 2022
  • - Article ID 5769784
  • - Research Article

The Conflicting Role of Caffeine Supplementation on Hyperoxia-Induced Injury on the Cerebellar Granular Cell Neurogenesis of Newborn Rats

Vivien Giszas | Evelyn Strauß | ... | Stefanie Endesfelder
  • Special Issue
  • - Volume 2022
  • - Article ID 8469756
  • - Research Article

Neonatal Oxidative Stress Impairs Cortical Synapse Formation and GABA Homeostasis in Parvalbumin-Expressing Interneurons

Till Scheuer | Stefanie Endesfelder | ... | Thomas Schmitz
  • Special Issue
  • - Volume 2022
  • - Article ID 2606880
  • - Research Article

Fetal Zone Steroids Show Discrete Effects on Hyperoxia-Induced Attenuation of Migration in Cultured Oligodendrocyte Progenitor Cells

Donna E. Sunny | Elisabeth L. Krüger | ... | Matthias Heckmann
  • Special Issue
  • - Volume 2022
  • - Article ID 2479626
  • - Research Article

Temporal Characterization of Microglia-Associated Pro- and Anti-Inflammatory Genes in a Neonatal Inflammation-Sensitized Hypoxic-Ischemic Brain Injury Model

Maria E. Bernis | Yvonne Schleehuber | ... | Hemmen Sabir
  • Special Issue
  • - Volume 2022
  • - Article ID 5784146
  • - Review Article

Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis

Stefanie Obst | Josephine Herz | ... | Ivo Bendix
  • Special Issue
  • - Volume 2022
  • - Article ID 9714669
  • - Research Article

Adaptation of the Oxygen Sensing System during Lung Development

Karin M. Kirschner | Simon Kelterborn | ... | Lina K. Sciesielski
  • Special Issue
  • - Volume 2022
  • - Article ID 3255296
  • - Research Article

The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain

Anna Maria Muccini | Nhi T. Tran | ... | Stacey J. Ellery
  • Special Issue
  • - Volume 2022
  • - Article ID 6421419
  • - Research Article

A20 Is Increased in Fetal Lung in a Sheep LPS Model of Chorioamnionitis

Steffen Kunzmann | Matthias Hütten | ... | Markus Fehrholz
  • Special Issue
  • - Volume 2021
  • - Article ID 6308255
  • - Research Article

Antioxidant Effect of Melatonin in Preterm Newborns

Lucia Marseglia | Eloisa Gitto | ... | Serafina Perrone
Oxidative Medicine and Cellular Longevity
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.