Oxidative Medicine and Cellular Longevity

The Role of Redox Homeostasis in Cancer Biology and Anticancer Therapy 2021


Publishing date
01 Mar 2022
Status
Closed
Submission deadline
05 Nov 2021

Lead Editor

1Renmin Hospital of Wuhan University, Wuhan, China

2Harvard University, Boston, USA

3University of Nebraska Medical Center, Omaha, USA

This issue is now closed for submissions.
More articles will be published in the near future.

The Role of Redox Homeostasis in Cancer Biology and Anticancer Therapy 2021

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Recently, there has been increasing interest in the role of oxygen free radicals in tumorigenesis and the dual function of antioxidants in the prevention, treatment, and therapy-related side effects of cancer. In comparison with healthy cells, cancer cells exhibit increased levels of reactive oxygen species (ROS) and changes in the expression of antioxidant enzymes. This alteration of cellular redox equilibrium with low amounts of ROS may have a variety of effects on cancer cells, influencing cell proliferation, invasion, metastasis, genetic stability, and sensitivity to anticancer drugs.

The altered oxidant and antioxidant balance results from increased production of ROS. Antioxidant enzyme inactivation, and consumption, can induce oxidative damage and lipid peroxidation processes leading to cell death. Therefore, the induction of oxidative stress generated by radiation and chemotherapeutic drugs is crucial to kill cancer cells. Meanwhile, the presence of high levels of antioxidants could counteract the pro-oxidant effect of radiation and anticancer drugs. Redox homeostasis might therefore be necessary for the maintenance of the malignant state.

The aim of this Special Issue is to publish high-quality original research as well as review articles about the role of redox homeostasis in cancer biology and anticancer therapy. We invite researchers to disseminate their recent results in the proposed topic.

Potential topics include but are not limited to the following:

  • Reactive oxygen species (ROS) mediated genomic and epigenomic instability
  • Molecular mechanisms of ROS in the modulation of cancer intracellular signalling pathways
  • Redox status and oxidative metabolism in cancer
  • Cancer biology and treatment with antioxidants
  • The role of redox associated noncoding RNAs in the aetiology of cancer
  • Oxidative stress-induced by conventional anticancer treatment with ionizing radiation
  • Modulation of redox signalling pathways for overcoming multidrug resistance in cancer
  • The role of intracellular antioxidants in radio- and chemoresistance

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 2543220
  • - Research Article

DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma

Xin Chen | Guohua Yang | ... | Shunfang Liu
  • Special Issue
  • - Volume 2022
  • - Article ID 4713518
  • - Research Article

ROS-Related miRNAs Regulate Immune Response and Chemoradiotherapy Sensitivity in Hepatocellular Carcinoma by Comprehensive Analysis and Experiment

Yangtao Xu | Xiaoqin He | ... | Ximing Xu
  • Special Issue
  • - Volume 2022
  • - Article ID 2623599
  • - Research Article

Therapy-resistant and -sensitive lncRNAs, SNHG1 and UBL7-AS1 promote glioblastoma cell proliferation

Mei Cao | Rong Ma | ... | Jian Zhao
  • Special Issue
  • - Volume 2022
  • - Article ID 8297011
  • - Research Article

The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis

Chen Zhao | Kewei Xiong | ... | Xiangpan Li
  • Special Issue
  • - Volume 2022
  • - Article ID 3665617
  • - Research Article

Glycosylation-Related Genes Predict the Prognosis and Immune Fraction of Ovarian Cancer Patients Based on Weighted Gene Coexpression Network Analysis (WGCNA) and Machine Learning

Chen Zhao | Kewei Xiong | ... | Xiangpan Li
  • Special Issue
  • - Volume 2022
  • - Article ID 4592170
  • - Research Article

Quantitative Proteomics Analysis Expands the Roles of Lysine β-Hydroxybutyrylation Pathway in Response to Environmental β-Hydroxybutyrate

Wanting Hou | Guobin Liu | ... | He Huang
  • Special Issue
  • - Volume 2022
  • - Article ID 9875295
  • - Corrigendum

Corrigendum to “System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma”

Jun Hui Xu | Yong Jun Guan | ... | Wei Xing Wang
  • Special Issue
  • - Volume 2022
  • - Article ID 4571319
  • - Research Article

Quantitative Proteomics Reveals the Role of Lysine 2-Hydroxyisobutyrylation Pathway Mediated by Tip60

Ning Wang | Yue Jiang | ... | Jian Li
  • Special Issue
  • - Volume 2022
  • - Article ID 5479491
  • - Research Article

Anlotinib Enhances the Antitumor Activity of High-Dose Irradiation Combined with Anti-PD-L1 by Potentiating the Tumor Immune Microenvironment in Murine Lung Cancer

Meng Yuan | Yirui Zhai | ... | Zhouguang Hui
  • Special Issue
  • - Volume 2022
  • - Article ID 4566851
  • - Research Article

The ROS/GRK2/HIF-1α/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin

Zhongyang Hong | Xianzheng Zhang | ... | Lingling Zhang
Oxidative Medicine and Cellular Longevity
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CiteScore9.300
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.