Oxidative Medicine and Cellular Longevity

Oxidative Stress in Microbial Diseases: Pathogen, Host, and Therapeutics


Publishing date
01 Oct 2018
Status
Published
Submission deadline
25 May 2018

1Federal University of Alfenas, Alfenas, Brazil

2Federal University of Minas Gerais, Belo Horizonte, Brazil

3University of Texas Health Science Center at Houston, Texas, USA


Oxidative Stress in Microbial Diseases: Pathogen, Host, and Therapeutics

Description

Antioxidant defenses in pathogenic microorganisms (bacteria, fungi, protozoan, and virus) are mediated by molecular mechanisms with variable complexity. In general, redox metabolism in microorganisms are based on rudimentary enzymatic process compared with the complex and multiscale enzymatic (e.g., superoxide dismutase, catalase, glutathione reductase, and glutathione S-transferase) and nonenzymatic (e.g., C and E vitamin, β-carotene, and uric acid) effectors broadly distributed in fluids and tissues of vertebrate hosts. As several antioxidant enzymes of pathogenic microorganisms are not expressed in eukaryotic hosts, these enzymes represent specific molecular targets potentially useful in rational drug design.

Regarding the pivotal role played by antioxidant system in maintaining the morphological and functional integrity of all microorganisms, disruptors of redox balance (e.g., inductors of oxidative stress or inhibitors of antioxidant molecules) have been proposed as candidates to new antimicrobial drugs. “Ideal” modulators of redox systems should be able to act on microbial metabolism with no or minimal interference on the host antioxidant defenses.

Interestingly, there is evidence that several drugs (e.g., anti-inflammatory, antineoplastic, antidepressant, anxiolytic, and antipsychotic) developed for diverse conditions also exhibit antimicrobial properties. These properties are supposedly based on the disruption of microbial redox metabolism. Accordingly, evidence from preclinical (in vitro and in vivo) and clinical studies opens new venues for drug repurposing and/or development of pharmacological strategies for the treatment of infectious diseases.

This special issue aims at creating an interdisciplinary platform to discuss the subcellular, cellular, and molecular basis of the metabolism redox associated with all levels of host-pathogen interaction and therapeutics. This issue accepts articles containing primary research results (in silico, in vitro, and in vivo) as well as studies based on secondary data, such as comprehensive and systematic review articles, which will illustrate and stimulate the continuing effort to understand the redox systems from the microbial metabolism, host-pathogen interaction, and treatment of infectious diseases.

Potential topics include but are not limited to the following:

  • Metabolism redox in pathogenic microorganisms
  • Oxidative stress and antioxidant defenses in infectious diseases
  • Prooxidant and antioxidant antimicrobial drugs
  • Analytical methods and instrumentation applied to the analysis of redox metabolism in pathogenic microorganisms, infectious diseases, and antimicrobial drugs

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 8159562
  • - Editorial

Oxidative Stress in Microbial Diseases: Pathogen, Host, and Therapeutics

Rômulo Dias Novaes | Antônio Lúcio Teixeira | Aline Silva de Miranda
  • Special Issue
  • - Volume 2018
  • - Article ID 4296985
  • - Research Article

Xylanase and Fermented Polysaccharide of Hericium caputmedusae Reduce Pathogenic Infection of Broilers by Improving Antioxidant and Anti-Inflammatory Properties

Sitong Zhang | Chunfeng Wang | ... | Guang Chen
  • Special Issue
  • - Volume 2018
  • - Article ID 6208067
  • - Review Article

Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway

Choongho Lee
  • Special Issue
  • - Volume 2018
  • - Article ID 8676578
  • - Review Article

Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach

Andréa Aparecida Santos Mendonça | Camila Morais Coelho | ... | Rômulo Dias Novaes
  • Special Issue
  • - Volume 2018
  • - Article ID 7695364
  • - Review Article

Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis

Madhur D. Shastri | Shakti Dhar Shukla | ... | Ronan F. O’Toole
  • Special Issue
  • - Volume 2018
  • - Article ID 3692752
  • - Research Article

Propionibacterium acnes Induces Intervertebral Disc Degeneration by Promoting iNOS/NO and COX-2/PGE2 Activation via the ROS-Dependent NF-κB Pathway

Yazhou Lin | Guoqing Tang | ... | Peng Cao
  • Special Issue
  • - Volume 2018
  • - Article ID 4904696
  • - Research Article

Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice

Domingos M. S. Pereira | Saulo J. F. Mendes | ... | Elizabeth S. Fernandes
  • Special Issue
  • - Volume 2018
  • - Article ID 4938649
  • - Research Article

Phagocytosis of Candida albicans Inhibits Autophagic Flux in Macrophages

Zhimin Duan | Qing Chen | ... | Min Li
  • Special Issue
  • - Volume 2018
  • - Article ID 1874985
  • - Research Article

N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter pylori Infection

Chuan Xie | Jian Yi | ... | Xu Shu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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