Oxidative Medicine and Cellular Longevity

Nrf2 in Host Defense: Over the Rainbow


Publishing date
31 May 2013
Status
Published
Submission deadline
11 Jan 2013

Lead Editor

1Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Bd.101, MD-D201, 111 TW Alexander Drive, Research Triangle Park, Durham, NC 27709, USA

2College of Pharmacy, The Catholic University of Korea, Room 408, 43-1 Yeokgok 2-Dong, Bucheon, Gyeonggi-Do 420-743, Republic of Korea

3Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, Durham, NC 27709, USA


Nrf2 in Host Defense: Over the Rainbow

Description

Nuclear factor, erythroid derived 2, like 2 (Nfe2l2), or NF-E2-related factor 2 (Nrf2) is discovered as a ubiquitous transcriptional regulator of antioxidant and detoxification genes. During the last decade or more, Nrf2 has been widely investigated as oxidative stress is understood to be a common occurrence in various critical disease conditions. Broad spectrum of Nrf2 functions in host defense has been uncovered in diverse cells and multiple organs insulted by various oxidants, xenobiotics, pathogens, and carcinogens. Recent advances of biomedical technologies have further provided genetics and genomics underlying Nrf2 in laboratory animals as well as in clinical settings. Overall, it is implicated that Nrf2 subsidizes host defense through modulation of complex pathways including well-characterized antioxidant activation as well as cell cycle and death, metabolism, immunity, development, and carcinogenesis.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular, cellular, genetic, and physiological mechanisms of Nrf2. We are not only interested in articles describing Nrf2-assocaited molecular mechanisms and disease pathogenesis which is not fully understood experimentally or clinically but also will be interested in exploration of unknown aspects or unpredicted outcomes of excessive Nrf2 activation in model systems. In addition, novel insights from advanced approach using molecular genetics, epigenetics, genomics, proteomics, and computational modeling are highly acclaimed. Potential topics include, but are not limited to:

  • Novel upstream and downstream mechanisms of Nrf2 regulation and homeostasis
  • Role of Nrf2 pathway in model systems of various critical disorders
  • Nrf2 in developmental cells and organs
  • Nrf2 pathway in toxicogenesis and carcinogenesis
  • Epigenetics and genetics of Nrf2 in oxidative stress conditions
  • Nrf2 agonists and supplemental antioxidants as potential therapeutic interventions
  • Latest technologies to assess the Nrf2-directed events

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/oximed/nrf2/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 975839
  • - Editorial

Nrf2 in Host Defense: Over the Rainbow

Hye-Youn Cho | Mi-Kyoung Kwak | Jingbo Pi
  • Special Issue
  • - Volume 2013
  • - Article ID 286524
  • - Review Article

Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

Hye-Youn Cho
  • Special Issue
  • - Volume 2013
  • - Article ID 848279
  • - Review Article

The Role of the Keap1/Nrf2 Pathway in the Cellular Response to Methylmercury

Yoshito Kumagai | Hironori Kanda | ... | Takashi Toyama
  • Special Issue
  • - Volume 2013
  • - Article ID 313510
  • - Research Article

Attenuation of -Amyloid-Induced Oxidative Cell Death by Sulforaphane via Activation of NF-E2-Related Factor 2

Chan Lee | Gyu Hwan Park | ... | Jung-Hee Jang
  • Special Issue
  • - Volume 2013
  • - Article ID 529219
  • - Review Article

Roles Nrf2 Plays in Myeloid Cells and Related Disorders

Eri Kobayashi | Takafumi Suzuki | Masayuki Yamamoto
  • Special Issue
  • - Volume 2013
  • - Article ID 839409
  • - Review Article

Mechanisms of Nrf2/Keap1-Dependent Phase II Cytoprotective and Detoxifying Gene Expression and Potential Cellular Targets of Chemopreventive Isothiocyanates

Biswa Nath Das | Young-Woo Kim | Young-Sam Keum
  • Special Issue
  • - Volume 2013
  • - Article ID 120305
  • - Research Article

Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway

Michelle R. Campbell | Mehmet Karaca | ... | Douglas A. Bell
  • Special Issue
  • - Volume 2013
  • - Article ID 305861
  • - Research Article

NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants

Jie Liu | Kai Connie Wu | ... | Curtis D. Klaassen
  • Special Issue
  • - Volume 2013
  • - Article ID 423965
  • - Research Article

Enhanced 4-Hydroxynonenal Resistance in KEAP1 Silenced Human Colon Cancer Cells

Kyeong-Ah Jung | Mi-Kyoung Kwak
  • Special Issue
  • - Volume 2013
  • - Article ID 957947
  • - Research Article

The Amelioration of N-Acetyl-p-Benzoquinone Imine Toxicity by Ginsenoside Rg3: The Role of Nrf2-Mediated Detoxification and Mrp1/Mrp3 Transports

Sang Il Gum | Min Kyung Cho
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.