Reactive oxygen (ROS) and nitrogen (RNS) species are generated as by-products of normal cellular metabolic activities and have been implicated in the pathogenesis of a variety of diseases. Oxidative stress is generated when the balance between ROS and antioxidants as well as antioxidant enzymes existing endogenously in the body are destroyed, resulting in endothelial cell damage.

Disruption of normal cellular homeostasis by redox signalling may result in cardiovascular disease, which roots from oxidative and inflammation-based disorders. Plants that possess medicinal properties are known for a long time in different cultures around the world to treat chronic diseases. A large number of potentially bioactive compounds, primarily polyphenols, alkaloids, glycosides, volatile oils, flavonoids, phenolic acids, have been explored from natural sources for their chemoprotective activities. Various bioactive compounds have been proved to improve endothelial injury through different mechanisms, such as antioxidant stress, anti-inflammatory, and anti-apoptosis.

The aim of this Special Issue is to attract original research articles and review articles with a focus on natural bioactive compounds that have potential therapeutic applications to treat cardiovascular diseases. We encourage submissions such as pre-clinical, clinical studies and reviews describing the interplay between oxidative stress and cardiovascular, especially cancer treatment-associated cardiotoxicity.

Potential topics include but are not limited to the following:

• Effects of natural bioactive compounds on ROS/RNS in vitro and in vivo
• Natural bioactive compound-triggered molecular pathways in oxidative stress-mediated diseases
• The putative role of oxidative stress and inflammation in the pathophysiology
• Role and diagnostic potential of natural bioactive compounds on circulating ROS
• Clinical studies based on natural bioactive compounds obtained from cardiovascular diseases
• Current research about preventing cancer treatment-associated cardiovascular dysfunction with a particular focus on oxidative stress and inflammation