Oxidative Medicine and Cellular Longevity

Genetic and Chemical Effects on Somatic and Germline Aging


Publishing date
01 Aug 2019
Status
Published
Submission deadline
05 Apr 2019

Lead Editor

1Brody School of Medicine at East Carolina University, Greenville, USA

2Southwest Medical University, Luzhou, China

3Yonsei University College of Medicine, Seoul, Republic of Korea

4North Carolina State University, Raleigh, USA


Genetic and Chemical Effects on Somatic and Germline Aging

Description

Somatic aging is a complex process characterized by gradual deterioration of physiological function that is observed at the genetic, molecular, and cellular levels. The role of genetic and chemical factors in the aging phenomenon extends to various research fields, including stem cell biology, diabetes, and cancer. Although the fundamental mechanisms behind the aging process are still poorly understood, increasing evidence shows that a progressive and irreversible accumulation of oxidative injury, caused by reactive oxygen species (ROS), impacts negatively on the aging process and contributes to impaired physiological function, increased incidence of age-related disease, and shortened lifespan.

In addition to somatic aging, several studies have shown that reproductive capabilities similarly decline with age (also termed germline aging). Germline tissue is the only tissue designed to support the development of an entire organism, and therefore it may be the ultimate source of stem cells for tissue replacement in diseased or injured individuals. Specifically, germline aging manifests as diminished germline stem cell (GSC) capacity and reduced germ cell numbers. Several reports have demonstrated that signals from the reproductive system influence somatic aging and vice versa. However, mechanisms governing this intricate process remain ill defined.

Therefore, this special issue will focus on the impact of genetic (e.g., Nrf2, Sirt1, and FOXO3a) and chemical factors (e.g., Resveratrol, T-BHQ, and other substances) on antioxidant defense mechanisms and age-induced somatic and germline aging, using both invertebrate and vertebrate model organisms, which may address fundamental biological questions regarding aging and development.

In this special issue, we invite investigators to contribute original research and review articles that will stimulate the continuing efforts to understand the molecular, cellular, and physiological mechanisms of how genetic and chemical factors influence somatic and germline aging.

Potential topics include but are not limited to the following:

  • Cellular defense mechanisms involved in somatic or germline aging
  • Interplay of oxidative stress and longevity pathways in somatic or germline aging
  • Novel readouts of oxidative stress and cellular and subcellular-scale morphological responses to oxidative damage
  • Somatic or germline mutations associated with aging
  • Ovary and testis as models for aging studies
  • Metabolic effects on somatic or germline aging
  • Genetic and chemical effects on somatic stem cell aging
  • Effects of growth signaling on aging

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 4684890
  • - Editorial

Genetic and Chemical Effects on Somatic and Germline Aging

Myon-Hee Lee | Huai-Rong Luo | ... | Adriana San-Miguel
  • Special Issue
  • - Volume 2019
  • - Article ID 4569614
  • - Research Article

Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)

Xiaoning Zhang | Yuwen Wang | ... | Feng Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 4025496
  • - Research Article

Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats

Rongfang He | Juan Zhang | ... | Miaoling Li
  • Special Issue
  • - Volume 2019
  • - Article ID 5276096
  • - Research Article

Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway

Gen-Xiang Mao | Xiao-Gang Xu | ... | Jing Yan
  • Special Issue
  • - Volume 2019
  • - Article ID 6379493
  • - Research Article

Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16

Zhaokang Zhang | Yannan Zhou | ... | Ya Jia
  • Special Issue
  • - Volume 2019
  • - Article ID 8030697
  • - Research Article

Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell

Min Chen | Min Chen | ... | Fei Gao
  • Special Issue
  • - Volume 2019
  • - Article ID 2860642
  • - Research Article

Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity in Caenorhabditis elegans

So-Hyeon Kim | Bo-Kyoung Kim | ... | Sang-Kyu Park
  • Special Issue
  • - Volume 2019
  • - Article ID 2818415
  • - Research Article

New Insights into Chronological Mobility of Retrotransposons In Vivo

Amr. R. Ghanam | Jun Cao | ... | Xiaoyuan Song
  • Special Issue
  • - Volume 2019
  • - Article ID 5768953
  • - Research Article

The Effects of Age and Reproduction on the Lipidome of Caenorhabditis elegans

Qin-Li Wan | Zhong-Lin Yang | ... | Gui-Sheng Wu
  • Special Issue
  • - Volume 2019
  • - Article ID 1607304
  • - Review Article

Triclosan: An Update on Biochemical and Molecular Mechanisms

Mohammad A. Alfhili | Myon-Hee Lee
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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