The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy
Table 3
Adjusted hazard ratios (95% confidence intervals) of biochemical recurrence (BCR) by metabolic syndrome component ().
Feature
% of sample
Model 1
Model 2
Model 3
Model 4
Hypertension
56.4
1.9 (1.1–3.3)
1.8 (1.0–3.1)
1.7 (0.99–2.9)
2.1 (1.1–3.8)
Diabetes
14.6
1.0 (0.52–2.1)
0.99 (0.48–2.0)
1.1 (0.52–2.2)
0.99 (0.48–2.1)
Obesity
31.6
1.1 (0.63–1.8)
1.0 (0.59–1.7)
1.0 (0.60–1.8)
0.97 (0.55–1.7)
Low HDL cholesterol
22.5
0.68 (0.36–1.3)
0.57 (0.30–1.1)
0.58 (0.30–1.1)
0.48 (0.24–1.0)
High triglycerides
41.4
0.90 (0.54–1.5)
0.92 (0.54–1.6)
0.92 (0.54–1.6)
1.1 (0.64–1.7)
Metabolic Syndrome
<3 features (referent)
75.2
1.0
1.0
1.0
≥3 features
24.8
1.4 (0.83–2.4)
1.4 (0.85–2.5)
1.5 (0.90–2.6)
—
Ordinal Model
0 features (referent)
23.2
1.0
1.0
1.0
1-2 features
52.0
0.96 (0.52–1.8)
0.85 (0.45–1.6)
0.75 (0.39–1.4)
—
≥3 features
24.8
1.4 (0.70–2.7)
1.3 (0.65–2.6)
1.3 (0.63–2.5)
—
Model 1: adjusted for age and race. Model 2: adjusted for age, race, and clinical characteristics (pre-operative PSA, Gleason’s grade, tumor stage, surgical margin status). Model 3: adjusted for age, race, clinical characteristics and smoking. Model 4: adjusted for age, race, clinical characteristics, smoking, and other metabolic syndrome components.
