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Prostate Cancer
Volume 2011, Article ID 380249, 3 pages
Research Article

Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study

1Servei de Patologia i, Hospital Universitari Sant Joan de Reus, Tarragona 43206, Reus, Spain
2Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Tarragona, Reus, Spain
3CRC Corporación Sanitària, Tarragona, Reus, Spain
4Servei de Radiologia i, Hospital Universitari Sant Joan de Reus, Tarragona, 43206 Reus, Spain
5Epidemiología, Estadística y Bioinformática, Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Reus, Spain

Received 14 February 2011; Accepted 11 April 2011

Academic Editor: Kenneth A. Iczkowski

Copyright © 2011 David Parada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Transrectal prostate biopsy is the standard protocol for the screening for prostate cancer. It helps to locate prostatic adenocarcinoma and plan treatment. However, the increasing number of prostate biopsies leads to considerably greater costs for the pathology laboratories. In this study, we compare the traditional method with an ink method in combination with a systematic histopathologic protocol. Methods. Two hundred consecutive transrectal prostate biopsy specimens were received from the radiology department. They were separated into two groups: one hundred were processed as six different specimens in the usual manner. The other one hundred were submitted in six containers, the apex, base, and middle section of which were stained different colours. The samples subject to the ink method were embedded in paraffin and placed in two cassettes which were sectioned using a specific protocol. Results. The comparative study of the nonink and ink methods for histopathologic diagnosis showed no statistical differences as far as diagnostic categories were concerned ( 𝑃 v a l u e < . 0 0 5 ). The number of PIN diagnoses increased when the ink method was used, but no statistical differences were found. The ink method led to a cost reduction of 48.86%. Conclusions. Our ink method combined with a specific histopathologic protocol provided the same diagnostic quality, tumor location information as the traditional method, and lower pathology expenses.