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Prostate Cancer
Volume 2011, Article ID 543272, 5 pages
Review Article

Review of Small Cell Carcinomas of the Prostate

1Department of Pathology, Escola Paulista de Medicina Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 740, São Paulo, SP, Brazil
2Presidente Dutra University Hospital, Federal University of Maranhao, São Luis, MA, Brazil
3Departments of Pathology and Urology, Cancer Institute of Ceara, CE, Brazil

Received 1 March 2011; Revised 16 May 2011; Accepted 30 May 2011

Academic Editor: Dengfeng Cao

Copyright © 2011 P. Furtado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Small cell carcinoma of the prostate is a rare neoplasm, with only a few series hitherto reported. A little less than half of the cases are associated with conventional acinar adenocarcinoma, which are usually high grade. Although consensus has not been reached, the majority of patients with small cell neuroendocrine carcinoma of the prostate have advanced disease at diagnosis and disproportionally low PSA levels compared to patients with conventional acinar adenocarcinoma. Treatment consists mainly of chemotherapy associated with surgery. Radiation therapy is reserved for selected cases. This study reviews the most up-to-date information on small cell carcinomas of the prostate.