Histone Deacetylase Inhibitors Restore Cell Surface Expression of the Coxsackie Adenovirus Receptor and Enhance CMV Promoter Activity in Castration-Resistant Prostate Cancer Cells
The effect of HDACi on surface CAR expression in C4-2b cells. Surface CAR expression was determined by flow cytometry in LNCaP cells (L = red lines), C4-2b cells (C = green lines), and C4-2b cells in the presence of HDACi (Cd or Cm = blue lines). Cd indicates that 100 ng/mL romidepsin was used, whereas Cm indicates a dose of 1 μM MS-275. (c) Graphical representation of the data. RD = romidepsin.
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