Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer
Table 1
Selection of potential markers/targets and pathways implicated in the development of radioresistant prostate cancer, their significance in predicting radiation therapy (RT) failure, and potential therapeutic inventions/agents.
Marker/target
Pathway
Prediction of RT failure
Potential therapeutic inventions/agents
D2-40
Metastatic
‡ (7–11)
Pelvic radiation
OLN+
Metastatic
‡ (12)
Pelvic radiation
AR
Hypersensitive
‡ (28)
AR silencing, MDV3100 [53] Statins [54, 55], abiraterone [56]