Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men
Table 4
Combined South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age).
Variables of interest
South Africa (Mixed, White and Black)
Senegal
Genotypes
OR (95% CI)
OR (95% CI)
CYP3A4 (rs2740574)
AA
1.00 (ref)
1.00 (ref)
AG
3.04 (2.13–4.35)**
1.51 (0.52–4.38)
GG
3.11 (1.63–5.93)
0.94 (0.54–1.65)
AG/GG
3.27 (2.30–4.65)**
1.13 (0.40–3.22)
CYP3A5 (rs776746)
GG
1.00 (ref)
1.00 (ref)
AG
1.74 (1.21–2.51)
0.97 (0.18–5.39)
AA
1.33 (1.05–1.67)
0.99 (0.50–1.99)
AG/AA
1.74 (1.25–2.41)
0.98 (0.24–3.97)
SRD5A2 V89L (rs523349)
GG
1.00 (ref)
1.00 (ref)
CG
0.66 (0.47–0.92)
0.36 (0.12–1.07)
CC
0.66 (0.45–0.95)
0.98 (0.60–1.59)
CG/CC
0.62 (0.45–0.86)
0.74 (0.30–1.86)
SRD5A2 A49T (rs9282858)
GG
1.00 (ref)
1.00 (ref)
AG
1.70 (1.19–2.43)
—
AA
—
—
AG/AA
1.70 (1.19–2.43)
—
—: too few/no genotypes to estimate ORs.
**
.
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