Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men

Table 4

Combined South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age).

Variables of interest	South Africa (Mixed, White and Black)	Senegal
Genotypes	OR (95% CI)	OR (95% CI)
CYP3A4 (rs2740574)
AA	1.00 (ref)	1.00 (ref)
AG	3.04 (2.13–4.35)**	1.51 (0.52–4.38)
GG	3.11 (1.63–5.93)	0.94 (0.54–1.65)
AG/GG	3.27 (2.30–4.65)**	1.13 (0.40–3.22)
CYP3A5 (rs776746)
GG	1.00 (ref)	1.00 (ref)
AG	1.74 (1.21–2.51)	0.97 (0.18–5.39)
AA	1.33 (1.05–1.67)	0.99 (0.50–1.99)
AG/AA	1.74 (1.25–2.41)	0.98 (0.24–3.97)
SRD5A2 V89L (rs523349)
GG	1.00 (ref)	1.00 (ref)
CG	0.66 (0.47–0.92)	0.36 (0.12–1.07)
CC	0.66 (0.45–0.95)	0.98 (0.60–1.59)
CG/CC	0.62 (0.45–0.86)	0.74 (0.30–1.86)
SRD5A2 A49T (rs9282858)
GG	1.00 (ref)	1.00 (ref)
AG	1.70 (1.19–2.43)	—
AA	—	—
AG/AA	1.70 (1.19–2.43)	—

—: too few/no genotypes to estimate ORs.
** 𝑃<0.0041.