Prostate Cancer / 2012 / Article / Tab 4

Research Article

Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men

Table 4

Combined South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age).

Variables of interestSouth Africa (Mixed, White and Black)Senegal
GenotypesOR (95% CI)OR (95% CI)

CYP3A4 (rs2740574)
 AA1.00 (ref)1.00 (ref)
 AG3.04 (2.134.35)**1.51 (0.52–4.38)
 GG 3.11 (1.63–5.93)0.94 (0.54–1.65)
 AG/GG3.27 (2.304.65)**1.13 (0.40–3.22)

CYP3A5 (rs776746)
 GG1.00 (ref)1.00 (ref)
 AG1.74 (1.21–2.51)0.97 (0.18–5.39)
 AA 1.33 (1.05–1.67)0.99 (0.50–1.99)
 AG/AA1.74 (1.25–2.41)0.98 (0.24–3.97)

SRD5A2 V89L (rs523349)
 GG1.00 (ref)1.00 (ref)
 CG0.66 (0.47–0.92)0.36 (0.12–1.07)
 CC 0.66 (0.45–0.95)0.98 (0.60–1.59)
 CG/CC0.62 (0.45–0.86)0.74 (0.30–1.86)

SRD5A2 A49T (rs9282858)
 GG1.00 (ref)1.00 (ref)
 AG1.70 (1.19–2.43)
 AG/AA1.70 (1.19–2.43)

—: too few/no genotypes to estimate ORs.
** .

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