| | Variables of interest | South Africa (Mixed, White and Black) | Senegal | | Genotypes | OR (95% CI) | OR (95% CI) |
| | CYP3A4 (rs2740574) | | | | AA | 1.00 (ref) | 1.00 (ref) | | AG | 3.04 (2.13–4.35)** | 1.51 (0.52–4.38) | | GG | 3.11 (1.63–5.93) | 0.94 (0.54–1.65) | | AG/GG | 3.27 (2.30–4.65)** | 1.13 (0.40–3.22) |
| | CYP3A5 (rs776746) | | | | GG | 1.00 (ref) | 1.00 (ref) | | AG | 1.74 (1.21–2.51) | 0.97 (0.18–5.39) | | AA | 1.33 (1.05–1.67) | 0.99 (0.50–1.99) | | AG/AA | 1.74 (1.25–2.41) | 0.98 (0.24–3.97) |
| | SRD5A2 V89L (rs523349) | | | | GG | 1.00 (ref) | 1.00 (ref) | | CG | 0.66 (0.47–0.92) | 0.36 (0.12–1.07) | | CC | 0.66 (0.45–0.95) | 0.98 (0.60–1.59) | | CG/CC | 0.62 (0.45–0.86) | 0.74 (0.30–1.86) |
| | SRD5A2 A49T (rs9282858) | | | | GG | 1.00 (ref) | 1.00 (ref) | | AG | 1.70 (1.19–2.43) | — | | AA | — | — | | AG/AA | 1.70 (1.19–2.43) | — |
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